一种针对Gm(26)的人源抗体：当不存在Gm(15)时，该抗原通常存在于IgG的γ-3链上。

A human antibody to Gm (26): an antigen usually present on the gamma-3 chain of IgG when Gm (15) is absent.

作者信息

Steinberg A G

出版信息

Vox Sang. 1977;33(5):266-9. doi: 10.1111/j.1423-0410.1977.tb04472.x.

DOI:10.1111/j.1423-0410.1977.tb04472.x

Abstract

An antibody to an antigen on IgG was found in the serum of a healthy American Negro, whose phenotype is Gm (1, 13, 15, 17). (When tested for Gm [1, 2, 3, 5, 6, 13, 15, 16, 17, 21].) Subsequent tests of serum samples from US blacks and whites, from Japanese, Ainu, San (Bushmen), Negros, Asiatic Indians and Jews from Cochin India demonstrated that the antibody detects an antigen that is usually present in a haplotype when Gm (15) is absent from it. This antigen had been identified using an antibody produced in a baboon. Tests of isolated myeloma proteins and of Fc and Fab fragments of IgG confirmed that the antigen [Gm (26) or Gm (u) - originally Gm (Pa)] is carried by the Fc portion of the gamma3-chain.

摘要

在一名健康美国黑人的血清中发现了一种针对IgG上一种抗原的抗体，其表型为Gm(1, 13, 15, 17)。（在检测Gm[1, 2, 3, 5, 6, 13, 15, 16, 17, 21]时）。随后对来自美国黑人和白人、日本人、阿伊努人、桑人（布须曼人）、黑人、亚洲印度人和科钦印度犹太人的血清样本进行检测，结果表明该抗体可检测到一种抗原，当单倍型中不存在Gm(15)时，该抗原通常存在于该单倍型中。这种抗原是用狒狒产生的抗体鉴定出来的。对分离的骨髓瘤蛋白以及IgG的Fc和Fab片段进行检测，证实该抗原[Gm(26)或Gm(u) - 最初为Gm(Pa)]由γ3链的Fc部分携带。