韩国胰岛素依赖型糖尿病患者的IgG重链（Gm）同种异型和HLA抗原

IgG heavy-chain (Gm) allotypes and HLA-antigens in insulin-dependent diabetes mellitus in Korea.

作者信息

Okimoto K, Nakao Y, Matsumoto H, Min H K, Kim E J, Lee T H, Yoon J S, Higa S, Oura T, Mimura G

出版信息

Tohoku J Exp Med. 1983 Dec;141 Suppl:283-7. doi: 10.1620/tjem.141.suppl_283.

DOI:10.1620/tjem.141.suppl_283

Abstract

Eighty-eight patients with insulin-dependent diabetes mellitus (IDDM) and seventy-two unrelated normal controls in Korea were studied for Gm allotypes and HLA-antigens. Ten Gm phenotypes were found among the Korean population. The phenotype frequencies of Gm axg (1,2,21), Gm ag (1,21), Gm agb0b3b5st (1,21, 11,13,10,15,16) and Gm agfb0b1b3b4b5 (1,21,3,11,5,13,14,10) were higher than the other Gm allotypes, but there was no significant difference between patients and controls. HLA-BW54 was found in 15% of patients who had any of those Gm allotypes (Gm axg, Gm agb0b3b5st, Gm ab0b3b5st). However there was no significant difference in frequency as compared with controls.

摘要

对韩国的88例胰岛素依赖型糖尿病（IDDM）患者和72例无关的正常对照者进行了Gm同种异型和HLA抗原研究。在韩国人群中发现了10种Gm表型。Gm axg（1,2,21）、Gm ag（1,21）、Gm agb0b3b5st（1,21, 11,13,10,15,16）和Gm agfb0b1b3b4b5（1,21,3,11,5,13,14,10）的表型频率高于其他Gm同种异型，但患者与对照之间无显著差异。在具有这些Gm同种异型（Gm axg、Gm agb0b3b5st、Gm ab0b3b5st）的患者中，15%发现有HLA - BW54。然而，与对照相比，频率无显著差异。