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三嗪杂化物的文献计量学综述：过去二十五年（2000 - 2025年）的合成、反应及应用

A bibliometric review of triazine hybrids: synthesis, reactions, and applications spanning the last quarter-century (2000-2025).

作者信息

Ali Hajar A, Ismail Mohamed A, Ghaith Eslam A

机构信息

Chemistry Department, Faculty of Science, Mansoura University El-Gomhoria Street Mansoura 35516 Egypt

Chemistry Department, Faculty of Science, New Mansoura University New Mansoura City Egypt.

出版信息

RSC Adv. 2025 Oct 21;15(47):39705-39770. doi: 10.1039/d5ra05849j. eCollection 2025 Oct 20.

DOI:10.1039/d5ra05849j
PMID:41127192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12538292/
Abstract

This comprehensive review delves into the intricate world of triazines, including their structures and the chemical diversity of their isomers. Additionally, this report encompasses a wide range of synthetic approaches, describing numerous reactions for attaining triazines, such as Bamberger, Bischler, inverse-electron-demand Diels-Alder, and Diels-Alder reactions. Moreover, this review describes the progress made in the chemistry of triazines, which is organized based on their reaction types, spotlighting the recent development. Accordingly, triazines stand out as a transformative strategy in the progress of synthetic chemistry due to their diverse applications in medicine, pharmacy, industry, and agriculture. Besides, triazine hybrids are important pharmacophores in the development of medications due to their captivating biological efficacy and biocompatibility. Consequently, this review presents a vast number of marketed drugs containing a triazine template while delineating their molecular mechanisms of action in disrupting disease pathways. Moreover, triazine cores are highlighted as flexible platforms for constructing and fine-tuning metal complexes and catalytic ligands in the period from 2000 to mid-2025. We anticipate that this review will be valuable to researchers focusing on the structural design and advancement of triazines.

摘要

这篇综述深入探讨了三嗪的复杂世界，包括它们的结构以及异构体的化学多样性。此外，本报告涵盖了广泛的合成方法，描述了众多用于合成三嗪的反应，如班伯格反应、比施勒反应、逆电子需求狄尔斯-阿尔德反应和狄尔斯-阿尔德反应。此外，本综述描述了三嗪化学领域取得的进展，这些进展是根据反应类型进行组织的，并突出了最新的发展。因此，由于三嗪在医学、制药、工业和农业中的广泛应用，它们在合成化学的发展中成为一种变革性策略。此外，三嗪杂化物因其迷人的生物活性和生物相容性，在药物开发中是重要的药效基团。因此，本综述展示了大量含有三嗪模板的上市药物，同时阐述了它们干扰疾病途径的分子作用机制。此外，在2000年至2025年年中期间，三嗪核心被视为构建和微调金属配合物及催化配体的灵活平台。我们预计，这篇综述对于专注于三嗪结构设计和发展的研究人员将具有重要价值。

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Exquisite Complex Reaction Cascade in the Natural 1,2,4-Triazine Assembly.天然1,2,4-三嗪组装中的精妙复合反应级联
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