Varghese Kevin, Fluck Ethan, Vetos Develyn, Chow Peter, Emge Drew
Division of Dermatology, University of Kansas Medical Center, Kansas City, KS, USA.
IDCases. 2025 Oct 13;42:e02401. doi: 10.1016/j.idcr.2025.e02401. eCollection 2025.
Cutaneous leishmaniasis is a parasitic infection caused by intracellular protozoa of the genus Leishmania. It is endemic to over 70 countries, with more than 30 sandfly species identified as vectors. Leishmania panamensis is a major cause of disease in Central and South America. The cutaneous form typically presents as chronic granulomatous papules or plaques on the face, arms, or legs, which may be nodular or ulcerative and can persist for years, often leaving disfiguring scars.Treatment generally involves systemic antimonials such as sodium stibogluconate or alternative agents including pentamidine, amphotericin B, and paromomycin. Surgical management is typically reserved for cosmetically sensitive areas or refractory lesions. We present a case of L. panamensis infection with a large ulcerated plaque that progressed despite initial surgical intervention, ultimately requiring systemic antimicrobial therapy.
皮肤利什曼病是一种由利什曼原虫属细胞内原生动物引起的寄生虫感染。它在70多个国家呈地方性流行，已确定30多种白蛉为传播媒介。巴拿马利什曼原虫是中美洲和南美洲疾病的主要病因。皮肤型通常表现为面部、手臂或腿部的慢性肉芽肿性丘疹或斑块，可能为结节状或溃疡性，可持续数年，常留下毁容性疤痕。治疗通常包括使用全身抗锑剂，如葡萄糖酸锑钠，或替代药物，包括喷他脒、两性霉素B和巴龙霉素。手术治疗通常适用于对美容敏感的部位或难治性病变。我们报告一例巴拿马利什曼原虫感染病例，患者有一个大的溃疡性斑块，尽管最初进行了手术干预仍进展，最终需要全身抗菌治疗。
