Charles N C, Bennett T W, Margolis S
Arch Ophthalmol. 1977 Nov;95(11):2034-7. doi: 10.1001/archopht.1977.04450110128016.
Congenital anomalies are rare in infancy following maternal varicella during pregnancy. Abnormalities do occur, however, and form a specific pattern including cicatrical skin lesions, atrophic limb, low birth weight, and chorioretinal scarring. We saw an infant who had immunologic evidence of varicella-zoster virus contact in utero, microphthalmos of one eye, and chorioretinal scarring of the fellow eye. Ophthalmologists confronted with such ocular anomalies in children should inquire about the possibility of maternal varicella during pregnancy. Conversely, infants born of mothers known to have had varicella during pregnancy should be examined for fundus abnormalities.
先天性异常在孕期患水痘的母亲所生婴儿中较为罕见。然而，异常情况确实会发生，并形成一种特定模式，包括瘢痕性皮肤病变、肢体萎缩、低出生体重和脉络膜视网膜瘢痕。我们见到一名婴儿，其有宫内感染水痘 - 带状疱疹病毒的免疫学证据，一只眼睛患有小眼畸形，另一只眼睛有脉络膜视网膜瘢痕。面对儿童出现此类眼部异常的眼科医生应询问孕期母亲患水痘的可能性。相反，已知孕期患水痘的母亲所生婴儿应检查眼底是否有异常。
