乙型血友病基因变异中的交叉反应物质。
Cross-reacting material in genetic variants of haemophilia B.
作者信息
Meyer D, Bidwell E, Larrieu M J
出版信息
J Clin Pathol. 1972 May;25(5):433-6. doi: 10.1136/jcp.25.5.433.
Abstract
Cross-reacting factor IX material (CRM) was immunologically detected in the plasma of 38 normal individuals and 21 out of 22 haemophilia B patients using a rabbit antibody to factor IX. The same reacting material was detected in only nine of these patients using a human antibody. These results indicate that the plasma of the majority of haemophilia B patients contains a protein-lacking biological activity but having antigenic determinants in common with normal factor IX.
摘要
使用针对凝血因子IX的兔抗体，在38名正常个体的血浆以及22名B型血友病患者中的21名患者血浆中免疫检测到交叉反应性因子IX物质（CRM）。而使用人抗体时，仅在其中9名患者中检测到相同的反应性物质。这些结果表明，大多数B型血友病患者的血浆中含有一种缺乏生物学活性但具有与正常凝血因子IX共同抗原决定簇的蛋白质。
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