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乙型血友病基因变异中的交叉反应物质。

Cross-reacting material in genetic variants of haemophilia B.

作者信息

Meyer D, Bidwell E, Larrieu M J

出版信息

J Clin Pathol. 1972 May;25(5):433-6. doi: 10.1136/jcp.25.5.433.

DOI:10.1136/jcp.25.5.433
PMID:4114698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC477341/
Abstract

Cross-reacting factor IX material (CRM) was immunologically detected in the plasma of 38 normal individuals and 21 out of 22 haemophilia B patients using a rabbit antibody to factor IX. The same reacting material was detected in only nine of these patients using a human antibody. These results indicate that the plasma of the majority of haemophilia B patients contains a protein-lacking biological activity but having antigenic determinants in common with normal factor IX.

摘要

使用针对凝血因子IX的兔抗体，在38名正常个体的血浆以及22名B型血友病患者中的21名患者血浆中免疫检测到交叉反应性因子IX物质（CRM）。而使用人抗体时，仅在其中9名患者中检测到相同的反应性物质。这些结果表明，大多数B型血友病患者的血浆中含有一种缺乏生物学活性但具有与正常凝血因子IX共同抗原决定簇的蛋白质。

相似文献

1
Cross-reacting material in genetic variants of haemophilia B.乙型血友病基因变异中的交叉反应物质。
J Clin Pathol. 1972 May;25(5):433-6. doi: 10.1136/jcp.25.5.433.
2
Detection of carriers of haemophilia B.乙型血友病携带者的检测
Br J Haematol. 1979 Jun;42(2):293-301. doi: 10.1111/j.1365-2141.1979.tb01133.x.
3
An immunological method for detection of the carrier of hemophilia B.一种检测乙型血友病携带者的免疫学方法。
Thromb Haemost. 1976 Nov 30;36(2):441-50.
4
Detection of genetic variants of haemophilia B with an immunosorbent technique.用免疫吸附技术检测乙型血友病的基因变异体。
Br J Haematol. 1973 Jul;25(1):63-8. doi: 10.1111/j.1365-2141.1973.tb01716.x.
5
Characterization of heterogeneity of haemophilia B for the detection of carriers.用于携带者检测的B型血友病异质性特征分析
Haemostasis. 1980;9(5):310-8. doi: 10.1159/000214370.
6
Variants of haemophilia B.B型血友病的变异型
Thromb Diath Haemorrh. 1972 Dec 31;28(3):489-95.
7
Two allotypes of factor IX present in haemophilia B.血友病B中存在两种凝血因子IX同种异型。
Scand J Haematol. 1986 Nov;37(5):411-6. doi: 10.1111/j.1600-0609.1986.tb02629.x.
8
Factor IX antigen by radioimmunoassay. Abnormal factor IX protein in patients on warfarin therapy and with hemophilia B.通过放射免疫测定法检测因子IX抗原。华法林治疗患者及血友病B患者中的异常因子IX蛋白。
J Clin Invest. 1977 May;59(5):900-10. doi: 10.1172/JCI108712.
9
Gene deletions in patients with haemophilia B and anti-factor IX antibodies.B型血友病和抗凝血因子IX抗体患者的基因缺失
Nature. 1983;303(5913):181-2. doi: 10.1038/303181a0.
10
Epitope mapping of human factor IX inhibitor antibodies.人凝血因子IX抑制物抗体的表位作图
Br J Haematol. 1994 Sep;88(1):166-73. doi: 10.1111/j.1365-2141.1994.tb04992.x.

引用本文的文献

1
Incidence, significance, and subtypes of hemophilia BM in a large population of hemophilia B patients.大量B型血友病患者中B型血友病携带者的发病率、意义及亚型
Blut. 1982 Jan;44(1):41-9. doi: 10.1007/BF00320685.
2
Factor IX antigen by radioimmunoassay. Abnormal factor IX protein in patients on warfarin therapy and with hemophilia B.通过放射免疫测定法检测因子IX抗原。华法林治疗患者及血友病B患者中的异常因子IX蛋白。
J Clin Invest. 1977 May;59(5):900-10. doi: 10.1172/JCI108712.
3
Purification and characterization of an abnormal factor IX (Christmas factor) molecule. Factor IX Chapel Hill.异常凝血因子IX（克里斯马斯因子）分子的纯化与特性分析。凝血因子IX查珀尔希尔。
J Clin Invest. 1978 Nov;62(5):1078-85. doi: 10.1172/JCI109213.
4
Further studies on factor IX antigen in hemophilia B.关于B型血友病中凝血因子IX抗原的进一步研究。
Blut. 1978 Oct 13;37(4):215-7. doi: 10.1007/BF00996723.

本文引用的文献

1
Effect of antihemophilic factor on one-stage clotting tests; a presumptive test for hemophilia and a simple one-stage antihemophilic factor assy procedure.抗血友病因子对一期凝血试验的影响；血友病的一种推定试验及一种简单的一期抗血友病因子测定方法。
J Lab Clin Med. 1953 Apr;41(4):637-47.
2
Genetic variants of hemophilia B: detection by means of a specific PTC inhibitor.B型血友病的基因变异：通过一种特定的PTC抑制剂进行检测。
J Clin Invest. 1968 Feb;47(2):360-5. doi: 10.1172/JCI105732.
3
Acquired inhibitors of plasma factor IX. A study of their induction, properties and neutralization.获得性血浆因子IX抑制剂。关于其诱导、特性及中和作用的研究。
Am J Med Sci. 1966 Jan;251(1):43-50. doi: 10.1097/00000441-196601000-00008.
4
Hemophilia A: polymorphism detectable by a factor 8 antibody.甲型血友病：可通过凝血因子 VIII 抗体检测到的多态性。
Science. 1969 Mar 7;163(3871):1071-2. doi: 10.1126/science.163.3871.1071.
5
Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.经典血友病（因子Ⅷ缺乏症）和血管性血友病的免疫学分型，以及关于抗血友病因子和加速素（因子Ⅴ）联合缺乏症和一种获得性抗血友病因子循环抗凝剂的观察
J Clin Invest. 1971 Jan;50(1):244-54. doi: 10.1172/JCI106480.
6
Immunologic studies of antihemophilic factor (AHF, factor VIII) II. Properties of cross-reacting material.抗血友病因子（AHF，因子VIII）的免疫学研究II. 交叉反应物质的特性
Blood. 1970 Jun;35(6):809-20.
7
The genetic heterogeneity of hemophilia B.乙型血友病的遗传异质性。
N Engl J Med. 1970 Jul 9;283(2):61-4. doi: 10.1056/NEJM197007092830203.
8
Factor 8 detection by hemagglutination inhibition: hemophilia A and von Willebrand's disease.通过血凝抑制检测因子VIII：甲型血友病和血管性血友病。
Science. 1971 Jan 15;171(3967):196-7. doi: 10.1126/science.171.3967.196.
9
Two types of haemophilia (A+ and A-): a study of 48 cases.两种血友病（A+型和A-型）：48例病例研究
Br J Haematol. 1969 Aug;17(2):163-71. doi: 10.1111/j.1365-2141.1969.tb01355.x.
10
Immunologic studies of antihemophilic factor (AHF, factor VIII): cross-reacting material in a genetic variant of hemophilia A.抗血友病因子（AHF，凝血因子VIII）的免疫学研究：A型血友病一种遗传变异体中的交叉反应物质
Blood. 1968 Dec;32(6):962-71.