Pirofsky B, Reid R R, Ramirez-Mateos J C, Bardana E J, August A
Clin Exp Immunol. 1972 Sep;12(1):89-101.
The immunologic effects of antithymocyte antisera therapy were evaluated in ten patients with myasthenia gravis. Equal numbers (5) of prior thymectomized and non-thymectomized subjects were studied. Seven patients did not have additional immunosuppressive therapy; three received minimal doses of corticosteroids or azathioprine. Increases in the production of γG and the C-3 component of complement, elevated erythrocyte sedimentation rates, complement binding to the erythrocyte surface and variable degrees of depression of primary humoral and cellular immune reactions were seen. Pre-existing thymectomy potentiated the action of antithymocyte antiserum inhibition of DNCB sensitization and skin graft rejection and intensified the degree of induced lymphopenia.
对10例重症肌无力患者评估了抗胸腺细胞抗血清疗法的免疫效应。研究了数量相等（各5例）的既往接受胸腺切除术和未接受胸腺切除术的受试者。7例患者未接受其他免疫抑制治疗；3例接受了小剂量的皮质类固醇或硫唑嘌呤。观察到γG生成增加、补体C-3成分升高、红细胞沉降率升高、补体与红细胞表面结合以及原发性体液免疫和细胞免疫反应出现不同程度的抑制。预先进行的胸腺切除术增强了抗胸腺细胞抗血清对二硝基氯苯致敏和皮肤移植排斥的抑制作用，并加剧了诱导性淋巴细胞减少的程度。
