McGuire T C, Crawford T B
Infect Immun. 1972 Oct;6(4):610-5. doi: 10.1128/iai.6.4.610-615.1972.
Immunoglobulin A (IgA) was demonstrated in equine serum and secretions. This immunoglobulin had a molecular weight extending from 150,000 to 700,000 and reacted with specific antihuman alpha-chain antiserum. Antigenic determinants specific for secretory IgA were demonstrated and found to be absent on serum IgA. Antigen binding activity was detected in IgA from tears. Purified IgA was antigenically distinct from equine IgG, IgM, IgG(T), and aggregating immunoglobulin. Quantitative studies demonstrated that IgA was the predominant immunoglobulin in tears and milk but not in colostrum. The electrophoretic mobility, size, presence of secretory component, and reaction with specific antihuman alpha-chain antiserum demonstrates that this immunoglobulin is the equine homologue of human IgA.
在马的血清和分泌物中发现了免疫球蛋白A（IgA）。这种免疫球蛋白的分子量在150,000至700,000之间，并与特异性抗人α链抗血清发生反应。已证实分泌型IgA特有的抗原决定簇，且发现血清IgA上不存在这些决定簇。在泪液中的IgA中检测到了抗原结合活性。纯化的IgA在抗原性上与马的IgG、IgM、IgG(T)和聚集免疫球蛋白不同。定量研究表明，IgA是泪液和乳汁中主要的免疫球蛋白，但初乳中不是。其电泳迁移率、大小、分泌成分的存在以及与特异性抗人α链抗血清的反应表明，这种免疫球蛋白是人类IgA的马同源物。
