McGuire T C
Immunology. 1976 Jan;30(1):17-24.
Comparison of immunoglobulin levels of nine horses before and after infection with equine infectious anaemia (EIA) virus demonstrated a significant depression of serum IgG(T) at 2 months (P less than 0-001) and at 1 year (P less than 0-01) after infection. In contrast, the levels of IgGa were significantly increased at both times after infection. Another sixteen horses with EIA for 1-4 months were examined and there was also significant depression (P less than 0-001) of IgG(T) when compared to pre-infection levels. No significant changes in IgG(T), IgGa and IgM were noted in fourteen normal horses housed for 2-7 months in the same manner as infected horses. Following DNP immunization there was a significant (P less than 0-02) decrease in the amount of IgG(T) antibody produced in five horses with EIA when compared to five normal horses. Metabolism studies with iodinated IgG(T) showed a significant (P less than 0-001) decrease in synthesis of this immunoglobulin in EIA-infected horses when compared to normal horses. Amounts of IgGa synthesized were similar in the two groups. Thus, persistent EIA viral infection suppresses the synthesis of IgG(T), an IgG subclass, without suppressing IgGa.
对9匹马感染马传染性贫血（EIA）病毒前后的免疫球蛋白水平进行比较，结果显示感染后2个月（P<0.001）和1年（P<0.01）时血清IgG(T)显著降低。相比之下，感染后两个时间点的IgGa水平均显著升高。对另外16匹感染EIA 1 - 4个月的马进行检查，与感染前水平相比，IgG(T)也显著降低（P<0.001）。以与感染马相同的方式饲养2 - 7个月的14匹正常马，其IgG(T)、IgGa和IgM未发现显著变化。与5匹正常马相比，5匹感染EIA的马经二硝基苯酚（DNP）免疫后，产生的IgG(T)抗体量显著减少（P<0.02）。用碘化IgG(T)进行的代谢研究表明，与正常马相比，感染EIA的马中这种免疫球蛋白的合成显著减少（P<0.001）。两组中合成的IgGa量相似。因此，持续性EIA病毒感染会抑制IgG(T)（一种IgG亚类）的合成，而不抑制IgGa。
