Liras P, Villanueva J R, Martín J F
J Gen Microbiol. 1977 Oct;102(2):269-77. doi: 10.1099/00221287-102-2-269.
Streptomyces griseus did not produce the polyene macrolide antibiotic candicidin during the initial growth phase characterized by rapid RNA synthesis. the absence of candicidin production when RNA or protein synthesis was inhibited by rifampicin or chloramphenicol suggests a transcriptionally controlled late formation of the candicidin synthases. Phosphate levels in the medium control the rate of DNA, RNA and protein synthesis. Depletion of phosphate appears to trigger the onset of candicidin synthesis after a drastic reduction of the rate of RNA synthesis. Changes in the ATP pool during the fermentation suggest that ATP may be the intracellular effector controlling the onset of antibiotic synthesis.
灰色链霉菌在以快速RNA合成特征的初始生长阶段不产生多烯大环内酯抗生素杀假丝菌素。利福平或氯霉素抑制RNA或蛋白质合成时杀假丝菌素产量的缺失表明杀假丝菌素合成酶的形成受转录控制且较晚。培养基中的磷酸盐水平控制DNA、RNA和蛋白质的合成速率。磷酸盐耗尽似乎在RNA合成速率急剧降低后触发杀假丝菌素合成的开始。发酵过程中ATP库的变化表明ATP可能是控制抗生素合成开始的细胞内效应物。
