Gund P, Shen T Y
J Med Chem. 1977 Sep;20(9):1146-52. doi: 10.1021/jm00219a007.
Conformational analysis of indomethacin and other nonsteroidal antiinflammatory drugs leads to formulation of a hypothetical complementary receptor site model. The same model can serve to describe the prostaglandin cyclooxygenase active site, and, indeed, arachidonic and other polyunsaturated fatty acids could be folded on the model in a manner which rationalizes their stereospecific transformation to cyclic endo-peroxides (PGG). The model rationalizes the structure-activity relationships of enzyme substrates and inhibitors and appears to be in agreement with biochemical studies of the enzyme.
对吲哚美辛及其他非甾体抗炎药的构象分析导致了一种假设的互补受体位点模型的形成。同样的模型可用于描述前列腺素环氧化酶的活性位点，实际上，花生四烯酸和其他多不饱和脂肪酸可以以一种使其立体特异性转化为环状内过氧化物（PGG）合理化的方式在该模型上折叠。该模型使酶底物和抑制剂的构效关系合理化，并且似乎与该酶的生化研究结果一致。
