剑麻的组胺释放活性和支气管收缩作用。
Histamine-releasing activity and bronchoconstricting effects of sisal.
作者信息
Nicholls P J, Evans E, Valić F, Zuskin E
出版信息
Br J Ind Med. 1973 Apr;30(2):142-5. doi: 10.1136/oem.30.2.142.
142-145. Extracts of dry and oiled sisal released histamine from pig and human but not from rat lung tissue. A suspension in Tyrode solution of the oil used for softening the sisal fibres had a pH of 8·1 and also released histamine from pig and human lung. The releasing activity was abolished when the pH of this suspension was adjusted to pH 7·4. As all the sisal extracts were adjusted to pH 7·4 for incubation with lung tissue, the histamine-releasing activity of sisal is unrelated to the presence of the oil. Significant (P < 0·01) mean reductions over the work shift of ventilatory capacity (PEF and FEV) were recorded in all the workers exposed to airborne sisal dust. These reductions were greater in combers than in drawers and spinners. Sisal collected from combing machines possessed more histamine-releasing activity than material from drawing and spinning machines. These results indicate that histamine release by sisal may be the cause of acute ventilatory capacity changes in sisal exposure.
142 - 145. 干燥的和涂油的剑麻提取物能使猪和人的肺组织释放组胺，但不能使大鼠肺组织释放组胺。用于软化剑麻纤维的油在台氏液中的悬浮液pH值为8.1，也能使猪和人的肺组织释放组胺。当将该悬浮液的pH值调至7.4时，释放活性消失。由于所有剑麻提取物在与肺组织孵育时都调至pH 7.4，所以剑麻的组胺释放活性与油的存在无关。所有暴露于空气中剑麻粉尘的工人在工作班次期间，通气能力（呼气峰流速和第一秒用力呼气量）均出现显著（P < 0.01）的平均下降。这些下降在梳麻工人中比在并条工和纺纱工中更明显。从梳麻机收集的剑麻比从并条机和纺纱机收集的材料具有更强的组胺释放活性。这些结果表明，剑麻释放组胺可能是剑麻暴露时急性通气能力变化的原因。
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