钙和锶与磷脂酰丝氨酸在组胺过敏分泌中的相互作用。

Spontaneous histamine release from isolated mast cells was found to be independent of calcium in the concentration range up to 1 m-mole/l. Phosphatidyl serine did not change the effect of calcium on spontaneous release.2. Spontaneous histamine release was found to vary with the strontium ion concentration. Graded increase in the release occurred as the concentration of strontium was raised from 1 to 10 m-mole/l. Phosphatidyl serine potentiated this action of strontium; the potentiation showed a graded increase as the phosphatidyl serine concentration was raised from 1 to 100 mug/ml.3. The activation of anaphylactic histamine release by calcium was potentiated by phosphatidyl serine; the degree of potentiation showed a graded increase as the calcium concentration was raised from 0.1 to 1.0 m-mole/l.4. The activation of anaphylactic histamine release by strontium showed little, if any, potentiation by phosphatidyl serine.5. The response of the mast cells, in terms of anaphylactic histamine release, to calcium, in the presence of optimal concentrations of phosphatidyl serine, was found to be similar to that observed in the presence of strontium alone.6. These observations are discussed in terms of the concepts of affinity and efficacy of the ions at their receptor sites.

发现从分离的肥大细胞中自发释放组胺在高达1毫摩尔/升的钙浓度范围内与钙无关。磷脂酰丝氨酸不改变钙对自发释放的影响。
发现自发组胺释放随锶离子浓度而变化。当锶浓度从1毫摩尔/升提高到10毫摩尔/升时，释放呈分级增加。磷脂酰丝氨酸增强了锶的这一作用；随着磷脂酰丝氨酸浓度从1微克/毫升提高到100微克/毫升，增强作用呈分级增加。
磷脂酰丝氨酸增强了钙对过敏性组胺释放的激活作用；随着钙浓度从0.1毫摩尔/升提高到1.0毫摩尔/升，增强程度呈分级增加。
磷脂酰丝氨酸对锶激活过敏性组胺释放几乎没有增强作用（如果有增强作用的话也很小）。
发现在存在最佳浓度磷脂酰丝氨酸的情况下，肥大细胞对钙的过敏性组胺释放反应与仅存在锶时观察到的反应相似。
根据离子在其受体部位的亲和力和效能概念对这些观察结果进行了讨论。

The interaction of calcium and strontium with phosphatidyl serine in the anaphylactic secretion of histamine.