右旋糖酐诱导大鼠腹膜肥大细胞组胺分泌的机制
On the mechanism of dextran-induced histamine secretion from rat peritoneal mast cells.
作者信息
Thompson H L, Leoutsakos A, Pearce F L
出版信息
Agents Actions. 1987 Apr;20(3-4):169-71. doi: 10.1007/BF02074659.
PMID:2440262
Abstract
The mechanism of histamine release induced from isolated rat peritoneal mast cells by clinical dextran was examined in detail. The putative involvement of cell-fixed IgE antibodies in the process was discounted by a number of experimental approaches. Instead, the characteristics of the release were found to be consistent with the interaction of the polysaccharide with specific glucoreceptors on the mast cell membrane.
摘要
详细研究了临床用右旋糖酐诱导大鼠离体腹膜肥大细胞释放组胺的机制。通过多种实验方法排除了细胞固定的IgE抗体在该过程中的假定作用。相反，发现释放的特征与多糖与肥大细胞膜上特定葡萄糖受体的相互作用一致。
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