Ladyzhenskaia I P, Vorob'eva M S, Dzagurov S G
Vopr Virusol. 1977 Sep-Oct(5):565-8.
The evidence of long-term survival of the tick-borne encephalitis complex viruses in primarily trypsinized brain cells of suckling mice inoculated in vivo is presented. The viability of the brain cell cultures from suckling mice inoculated with an attenuated strain was shown to be higher than that of a similar culture of the brain cells from suckling mice infected with a virulent strain. The infectious virus could be recovered for over 200 days of the existence of these cultures. The experimental results appear to be another confirmation of the capacity of viruses of the tick-borne encephalitis complex, particularly of the attenuated strains, for persistence.
本文呈现了蜱传脑炎复合病毒在体内接种的乳鼠经胰蛋白酶处理的原代脑细胞中长期存活的证据。结果表明，接种减毒株的乳鼠脑细胞培养物的活力高于感染强毒株的乳鼠脑细胞类似培养物。在这些培养物存在的200多天里都能回收感染性病毒。实验结果似乎再次证实了蜱传脑炎复合病毒，特别是减毒株，具有持续存在的能力。
