Thomson D S, Evans D P
Clin Exp Immunol. 1973 Apr;13(4):537-44.
The ability of disodium cromoglycate to inhibit IgE-mediated cutaneous anaphylaxis in the rat and release of histamine from peritoneal mast cells has been studied. Only when drug and antigen were presented to the sensitized cells simultaneously was a dose-dependent inhibition demonstrable. After the drug had been given alone, in the absence of antigen, either or it had little or no action when given again at antigen challenge. , this refractory state was reversible. It is suggested that disodium cromoglycate may act by releasing some factor capable of inhibiting the release of mediators from the mast cell.
已对色甘酸钠抑制大鼠IgE介导的皮肤过敏反应及从腹膜肥大细胞释放组胺的能力进行了研究。仅当药物和抗原同时作用于致敏细胞时，才能显示出剂量依赖性抑制作用。在单独给予药物后，在无抗原的情况下，或者在抗原激发时再次给予药物，其作用很小或无作用。然而，这种不应性状态是可逆的。提示色甘酸钠可能通过释放某种能够抑制肥大细胞介质释放的因子而发挥作用。
