de Lourdes Arruzazabala M, Alvarez R G
Agents Actions. 1982 Dec;12(5-6):596-600. doi: 10.1007/BF01965066.
Transmural electrical stimulation was carried out on innervated strips of the longitudinal muscle of guinea pig ileum. Disodium cromoglycate (DSCG) inhibited the electrically induced contractions. Five minutes later, prostaglandin E2 (2.5 ng/ml) was added to the bath and it reversed the action of DSCG. Furthermore, DSCG inhibits significantly the guinea pig ileum contractions induced by nicotine and also those induced by histamine and acetylcholine on ileum denervated by cooling. These results suggest that DSCG effects on guinea pig ileum contraction are mediated by membrane-stabilizing properties of this drug on smooth muscle fibres as well as on myenteric plexus.
对豚鼠回肠纵肌的有神经支配条带进行透壁电刺激。色甘酸钠（DSCG）抑制电诱导的收缩。五分钟后，向浴槽中加入前列腺素E2（2.5 ng/ml），它逆转了DSCG的作用。此外，DSCG显著抑制尼古丁诱导的豚鼠回肠收缩，以及冷却去神经的回肠上组胺和乙酰胆碱诱导的收缩。这些结果表明，DSCG对豚鼠回肠收缩的作用是由该药物对平滑肌纤维以及肌间神经丛的膜稳定特性介导的。
