Das M, Stiehm E R, Borut T, Feig S A
Am J Clin Nutr. 1977 Dec;30(12):1949-52. doi: 10.1093/ajcn/30.12.1949.
Mononuclear cells of malnourished children contain diminished activity of phosphoglycerate kinase and pyruvate kinase (PK). The PK activity of these cells correlates well with the percentage of circulating thymus-derived lymphocytes (T-cells). Phytohemagglutinin causes an immediate increase in PK activity of mononuclear cells of malnourished patients. The correlation of PK activity with T-cells and the response of PK activity to phytohemagglutinin are in distinct contrast to observed perturbations of neonatal mononuclear cell metabolism. The relationship of the metabolic alterations to the pathophysiology of the immune system in malnutrition has not yet been defined.
营养不良儿童的单核细胞中磷酸甘油酸激酶和丙酮酸激酶（PK）的活性降低。这些细胞的PK活性与循环中的胸腺来源淋巴细胞（T细胞）百分比密切相关。植物血凝素可使营养不良患者单核细胞的PK活性立即增加。PK活性与T细胞的相关性以及PK活性对植物血凝素的反应与新生儿单核细胞代谢所观察到的紊乱形成鲜明对比。营养不良时代谢改变与免疫系统病理生理学之间的关系尚未明确。
