Botham S K, Holt P F
Br J Ind Med. 1973 Jul;30(3):232-6. doi: 10.1136/oem.30.3.232.
232-236. Following 24 hours inhalation by guinea-pigs of powdered glass dust, the pulmonary effects over the succeeding month differed from those previously observed to follow inhalation of glass fibre in that (1) fewer erythrocytes escaped from the capillaries, (2) very few giant cells were produced, (3) erythrocytes and intracellular glass particles were cleared more readily because junctions between respiratory and terminal bronchioles were not blocked by giant cells, (4) intracellular granules containing Perls-positive material did not appreciably increase in number or intensity of staining during the month, and (5) particles were not coated with Perls-positive material during the time that pseudo-asbestos bodies would be formed from glass fibres. The difference between the effects of chemically similar glass powder and fibre during a month in a guinea-pig lung is considered to be due to the morphology of the inhaled particle.
232 - 236。豚鼠吸入玻璃粉尘24小时后，在随后的一个月里肺部产生的效应与之前吸入玻璃纤维后观察到的效应有所不同，具体表现为：（1）从毛细血管逸出的红细胞较少；（2）产生的巨细胞极少；（3）红细胞和细胞内玻璃颗粒更容易被清除，因为呼吸性细支气管和终末细支气管之间的连接处未被巨细胞阻塞；（4）含珀尔斯阳性物质的细胞内颗粒在这一个月内数量和染色强度并未明显增加；（5）在玻璃纤维会形成假石棉小体的这段时间内，颗粒未被珀尔斯阳性物质包裹。豚鼠肺部在一个月内化学性质相似的玻璃粉和玻璃纤维产生的效应差异被认为是由于吸入颗粒的形态所致。
