Campbell B C, Baird A W
Br J Ind Med. 1977 Nov;34(4):298-304. doi: 10.1136/oem.34.4.298.
The incidence of lead poisoning in industry has fallen dramatically since the beginning of the twentieth century. This reduction has been partly attributable to increased awareness, improved ventilation and hygiene facilities, and technical changes which have allowed other substances to replace lead, but improved medical surveillance of workers exposed to lead in certain defined industries has also been important. Not all industries where lead exposure can occur are at present covered by specific regulations dealing with lead, however. We report the diagnosis and treatment of eleven oxyacetylene metal burners involved in the demolition of a railway station, who rapidly developed frank lead poisoning. The most suitable measurements to employ in evaluating such a population are considered. The selection, based on blood lead and haemoglobin measurements, of those who should receive further treatment is discussed. Symptoms were found to be more nearly related to indices of effect or toxicity of lead than to indices of exposure or absorption. The effects of chelation therapy upon symptoms, blood lead, haemoglobin and urinary porphyrins are recorded. The need for careful follow-up is illustrated.
自二十世纪初以来,工业中铅中毒的发生率已大幅下降。这种下降部分归因于意识的提高、通风和卫生设施的改善,以及技术变革使其他物质能够替代铅,但对某些特定行业中接触铅的工人加强医学监测也很重要。然而,目前并非所有可能发生铅暴露的行业都受到处理铅问题的具体法规的覆盖。我们报告了11名参与火车站拆除工作的氧乙炔金属气割工的诊断和治疗情况,他们迅速发展为明显的铅中毒。讨论了用于评估这类人群的最合适测量方法。基于血铅和血红蛋白测量结果,讨论了选择应接受进一步治疗的人员的问题。发现症状与铅的效应或毒性指标的关系比与暴露或吸收指标的关系更为密切。记录了螯合疗法对症状、血铅、血红蛋白和尿卟啉的影响。说明了仔细随访的必要性。