接受左旋甲状腺素抑制或替代治疗患者的血清甲状腺素水平。
Serum thyroxine levels in patients receiving L-thyroxine suppression or replacement therapy.
作者信息
Kahn A
出版信息
Can Med Assoc J. 1973 Aug 18;109(4):279-81.
Abstract
Serum thyroxine (T(4)) and protein-bound iodine (PBI) levels were measured in 140 adult patients receiving L-thyroxine, 0.2 or 0.3 mg. daily for at least six months, as suppression or replacement therapy. All were judged to be clinically euthyroid at the time of the measurements. The mean PBI was 8.3 mug./100 ml. and the mean T(4) was 10.8 mug./100 ml. The range of values for the PBI was 3.5 to 13.2 and for the T(4) was 3.1 to 17.0. Because of the wide range of values, it is considered that the judgement of whether a patient is euthyroid on L-thyroxine therapy should be based primarily on clinical evaluation and only secondarily on serum T(4) or PBI levels.
摘要
对140名成年患者进行了血清甲状腺素（T(4)）和蛋白结合碘（PBI）水平的测定，这些患者每天接受0.2或0.3毫克L-甲状腺素治疗至少六个月，作为抑制或替代疗法。在测量时，所有患者均被判定临床甲状腺功能正常。平均PBI为8.3微克/100毫升，平均T(4)为10.8微克/100毫升。PBI的值范围为3.5至13.2，T(4)的值范围为3.1至17.0。由于值的范围较宽，因此认为判断接受L-甲状腺素治疗的患者是否甲状腺功能正常应主要基于临床评估，其次才是血清T(4)或PBI水平。
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本文引用的文献
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N Engl J Med. 1964 Feb 27;270:439-42. doi: 10.1056/NEJM196402272700903.
2
DETERMINATION OF THYROXINE UTILIZING THE PROPERTY OF PROTEIN-BINDING.利用蛋白质结合特性测定甲状腺素
J Clin Endocrinol Metab. 1964 Feb;24:187-96. doi: 10.1210/jcem-24-2-187.
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BINDING OF THYROXINE BY SERUM PROTEINS EVALUATED BY EQUILIBRUM DIALYSIS AND ELECTROPHORETIC TECHNIQUES. ALTERATIONS IN NONTHYROIDAL ILLNESS.通过平衡透析和电泳技术评估血清蛋白对甲状腺素的结合。非甲状腺疾病中的改变。
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