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通过二硝基苯化和硫烷化引入同源血清白蛋白中的新抗原决定簇的表征。

Characterization of new antigenic determinants introduced into homologous serum albumin by dinitrophenylation and sulphanylation.

作者信息

Rubin B, Aasted B

出版信息

Immunology. 1973 Sep;25(3):399-408.

PMID:4126352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423052/
Abstract

Studies on the immune response against hapten-autologous protein carriers in mice, guinea-pigs and rabbits have shown that the new antigenic determinants introduced in the carrier molecule by the hapten coupling reaction play an important role in the induction of both immunity and tolerance to these conjugates. The present experiments were designed to elucidate the specificity of the new antigenic determinants induced (1) by different haptens through the same coupling procedure and (2) by the same hapten coupled by different procedures. The results showed that both the nature of the hapten and the coupling procedure played a role in the serological specificity of the new antigenic determinants.

摘要

对小鼠、豚鼠和兔子针对半抗原 - 自体蛋白载体的免疫反应的研究表明，半抗原偶联反应在载体分子中引入的新抗原决定簇在诱导针对这些偶联物的免疫和耐受中起重要作用。本实验旨在阐明（1）通过相同偶联程序由不同半抗原诱导的以及（2）通过不同程序偶联的相同半抗原诱导的新抗原决定簇的特异性。结果表明，半抗原的性质和偶联程序均在新抗原决定簇的血清学特异性中起作用。

相似文献

1
Characterization of new antigenic determinants introduced into homologous serum albumin by dinitrophenylation and sulphanylation.通过二硝基苯化和硫烷化引入同源血清白蛋白中的新抗原决定簇的表征。
Immunology. 1973 Sep;25(3):399-408.
2
Studies on the induction of antibody synthesis against sulfanilic acid in rabbits. I. Effect of the number of hapten molecules introduced in homologous protein on antibody synthesis against the hapten and the new antigenic determinants.家兔中抗对氨基苯磺酸抗体合成的诱导研究。I. 同源蛋白中引入的半抗原分子数量对针对半抗原和新抗原决定簇的抗体合成的影响。
Eur J Immunol. 1972 Feb;2(1):5-11. doi: 10.1002/eji.1830020103.
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Studies on the induction of antibody synthesis against sulfanilic acid in rabbits. II. Effect of antibodies directed against new antigenic determinants in homologous protein. The impact on the primary immune response.
Scand J Immunol. 1972;1(2):125-34. doi: 10.1111/j.1365-3083.1972.tb00591.x.
4
Regulation of antibody response in vitro. IV. Heavy chain antigenic determinants on hapten-specific memory cells.体外抗体应答的调节。IV. 半抗原特异性记忆细胞上的重链抗原决定簇。
J Immunol. 1972 Dec;109(6):1163-73.
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Cross-reactions between 2,4-dinitrophenyl and 5-acetouracil groups.2,4-二硝基苯基与5-乙酰尿嘧啶基团之间的交叉反应。
J Immunol. 1971 Jun;106(6):1431-40.
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[Determination by weight of the primary antibody response to the antigenic determinant of 2,4-dinitrophenol].
G Batteriol Virol Immunol Ann Osp Maria Vittor Torino. 1970 Sep-Oct;63(9):502-3.
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9
Secretion of monospecific anti-hapten IgG antibodies by rabbit immunocytes.
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PCA reactions in guinea pigs: elicitation by antigens of related structure and inhibition by haptens.豚鼠中的PCA反应：相关结构抗原的引发及半抗原的抑制作用
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Infect Immun. 1994 Dec;62(12):5327-34. doi: 10.1128/iai.62.12.5327-5334.1994.

本文引用的文献

1
THE IMMUNE RESPONSE TO AZO-PROTEIN CONJUGATES IN RABBITS UNRESPONSIVE TO THE PROTEIN CARRIERS.兔对蛋白质载体无反应时对偶氮蛋白缀合物的免疫反应。
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Delayed hypersensitivity to hapten-protein conjugates. I. The effect of carrier protein and site of attachment to hapten.对半抗原 - 蛋白质结合物的迟发型超敏反应。I. 载体蛋白及与半抗原连接位点的影响
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Effect of neonatal injections of protein on the immune response to protein-hapten complexes.新生期注射蛋白质对蛋白质-半抗原复合物免疫反应的影响。
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Immunological specificity of delayed and immediate hypersensitivity reactions.迟发型和速发型超敏反应的免疫特异性
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5
Azoproteins. II. A spectrophotometric study of the coupling of diazotized arsanilic acid with proteins.偶氮蛋白。II. 重氮化对氨基苯胂酸与蛋白质偶联的分光光度研究。
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Studies of hypersensitivity to low molecular weight substances. III. The 2,4-dinitrophenyl group as a determinant in the preciptin reaction.低分子量物质超敏反应的研究。III. 2,4-二硝基苯基作为沉淀素反应中的一个决定簇
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[Specific, complement-dependent hemolysis of sheep erythrocytes by antiserum to azo hapten groups].[偶氮半抗原基团抗血清对绵羊红细胞的特异性、补体依赖性溶血作用]
J Infect Dis. 1952 Nov-Dec;91(3):268-75. doi: 10.1093/infdis/91.3.268.
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The effect of tolerance on the specificity of the antibody response and on immunogenicity. Antibody response to conformationally and chemically altered antigens.耐受性对抗体反应特异性及免疫原性的影响。针对构象和化学改变抗原的抗体反应。
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The effect of cross-reacting antigens on the tolerant state.交叉反应抗原对耐受状态的影响。
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10
The nature of an antigenic determinant.抗原决定簇的性质。
J Immunol. 1966 Jul;97(1):1-11.