耐受性对抗体反应特异性及免疫原性的影响。针对构象和化学改变抗原的抗体反应。
The effect of tolerance on the specificity of the antibody response and on immunogenicity. Antibody response to conformationally and chemically altered antigens.
作者信息
St Rose J E, Cinader B
出版信息
J Exp Med. 1967 Jun 1;125(6):1031-55. doi: 10.1084/jem.125.6.1031.
Abstract
Animals were rendered tolerant to human albumin and were then immunized with azo derivatives of human albumin which differed in the number of hapten groups per molecule and in the extent of conformational change. The incidence and specificity of the resulting antibody response was studied and the presence of antibody to azo groups and to conformationally altered protein determinants was demonstrated. Reactivity with the tolerance-inducing antigen was shown to be due to antibodies directed against conformationally altered protein determinants. The difference in the response of tolerant animals to hapten-poor and hapten-rich derivatives was attributed to the extent of conformational alteration. A genetic factor appeared to be implicated in the capacity of tolerant animals to respond to an antigen which cross-reacts with tolerance-inducing macromolecules.
摘要
使动物对人白蛋白产生耐受性，然后用每分子中半抗原基团数量不同且构象变化程度不同的人白蛋白偶氮衍生物进行免疫。研究了由此产生的抗体反应的发生率和特异性，并证明了存在针对偶氮基团和构象改变的蛋白质决定簇的抗体。与诱导耐受性抗原的反应性被证明是由于针对构象改变的蛋白质决定簇的抗体。耐受性动物对半抗原含量低和半抗原含量高的衍生物反应的差异归因于构象改变的程度。一个遗传因素似乎与耐受性动物对与诱导耐受性大分子发生交叉反应的抗原的反应能力有关。
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引用本文的文献
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The effect of cross-reacting antigens on the tolerant state.交叉反应抗原对耐受状态的影响。
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Development of anti-tissue antibodies in rats.大鼠抗组织抗体的产生
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Selective immune reactivity to DNP-poly-L-lysine in randomly bred guinea-pigs.随机繁殖豚鼠对二硝基苯基-聚-L-赖氨酸的选择性免疫反应性。
Immunology. 1969 May;16(5):581-8.
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Heterogeneity of the cellular immune response. I. Kinetics of lymphocyte stimulation during sensitization and recovery from tolerance.细胞免疫反应的异质性。I. 致敏和从耐受性恢复过程中淋巴细胞刺激的动力学。
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Specificity of cellular immune responses. Antigen concentration dependence of stimulation of DNA synthesis in vitro by specifically sensitized cells, as an expression of the binding characteristics of cellular antibody.细胞免疫反应的特异性。特异性致敏细胞在体外刺激DNA合成时抗原浓度的依赖性，作为细胞抗体结合特性的一种表现。
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本文引用的文献
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The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.蛋白质在经单宁酸处理的红细胞上的吸附以及随后抗蛋白质血清引起的血细胞凝集。
J Exp Med. 1951 Feb;93(2):107-20. doi: 10.1084/jem.93.2.107.
2
THE IMMUNE RESPONSE TO AZO-PROTEIN CONJUGATES IN RABBITS UNRESPONSIVE TO THE PROTEIN CARRIERS.兔对蛋白质载体无反应时对偶氮蛋白缀合物的免疫反应。
Immunology. 1964 Nov;7(6):616-25.
3
4
STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.人工抗原的研究。III. 豚鼠对半抗原-聚-L-赖氨酸缀合物免疫反应的遗传控制。
J Exp Med. 1963 Dec 1;118(6):953-7. doi: 10.1084/jem.118.6.953.
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Antibody to enzymes--a three-component system. Introduction: immunochemistry of enzymes.酶抗体——一种三组分系统。引言：酶的免疫化学
Ann N Y Acad Sci. 1963 May 8;103:495-548. doi: 10.1111/j.1749-6632.1963.tb53717.x.
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Termination of acquired immunological tolerance to protein antigens following immunization with altered protein antigens.用改变后的蛋白质抗原免疫后，对蛋白质抗原获得性免疫耐受的终止。
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Effect of neonatal injections of protein on the immune response to protein-hapten complexes.新生期注射蛋白质对蛋白质-半抗原复合物免疫反应的影响。
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The immune response of rabbits tolerant to bovine serum albumin to the injection of other heterologous serum albumins.对牛血清白蛋白产生耐受的兔子对注射其他异种血清白蛋白的免疫反应。
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