柯尔斯滕肉瘤病毒核酸序列的研究：一种含RNA的哺乳动物肉瘤病毒形成的模型。
Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus.
作者信息
Scolnick E M, Rands E, Williams D, Parks W P
出版信息
J Virol. 1973 Sep;12(3):458-63. doi: 10.1128/JVI.12.3.458-463.1973.
Abstract
The genetic information contained in the Kirsten and Moloney strains of mammalian RNA-containing sarcoma viruses has been analyzed by RNA . (3)H-DNA hybridization. Kirsten sarcoma virus has been found to possess two distinct sets of nucleic acid sequences. One set of sequences is contained in murine type C helper virus, and the other set is contained in rat type C helper virus. Moloney sarcoma virus contains sequences of murine type C helper virus but not of rat type C helper virus. The results indicate that Kirsten sarcoma virus arose through a process of recombination between Kirsten murine leukemia virus and nucleic acid sequences found in rat cells. A model is suggested for the formation of transforming type C viruses involving the transduction of oncogenic information.
摘要
已通过RNA·(3)H-DNA杂交分析了含有哺乳动物RNA的肉瘤病毒的柯斯顿株和莫洛尼株中所含的遗传信息。已发现柯斯顿肉瘤病毒拥有两组不同的核酸序列。一组序列存在于鼠类C型辅助病毒中，另一组序列存在于大鼠C型辅助病毒中。莫洛尼肉瘤病毒含有鼠类C型辅助病毒的序列，但不含有大鼠C型辅助病毒的序列。结果表明，柯斯顿肉瘤病毒是通过柯斯顿鼠白血病病毒与大鼠细胞中发现的核酸序列之间的重组过程产生的。提出了一个涉及致癌信息转导的转化型C病毒形成模型。
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