哈维肉瘤病毒：一种带有大鼠遗传信息的第二种鼠类C型肉瘤病毒。
Harvey sarcoma virus: a second murine type C sarcoma virus with rat genetic information.
作者信息
Scolnick E M, Parks W P
出版信息
J Virol. 1974 Jun;13(6):1211-9. doi: 10.1128/JVI.13.6.1211-1219.1974.
Abstract
The nucleic acid sequences found in the Harvey strain of murine sarcoma virus have been analyzed by RNA.[(3)H]DNA and [(3)H]RNA.DNA hybridization techniques. The Harvey strain of murine sarcoma virus has been found to possess at least two sets of nucleic acid sequences. One set of sequences is contained in the Moloney strain of mouse type-C virus, and the other set is contained in DNA transcripts synthesized in endogenous reactions containing rat type-C virus(es). The nucleic acid sequences that are detected in the Harvey sarcoma virus with the DNA probes synthesized from the rat type-C virus(es) are related to the rat sequences detected in the Kirsten strain of murine sarcoma virus. The results support the model that both Kirsten and Harvey sarcoma viruses arose through a process of recombination or reassortment between mouse type-C viruses and sequences in rat cells and suggest that the information for transformation of fibroblasts may be contained in the rat type-C or cellular genome.
摘要
已通过RNA.[(3)H]DNA和[(3)H]RNA.DNA杂交技术分析了鼠肉瘤病毒哈维株中发现的核酸序列。已发现鼠肉瘤病毒哈维株至少拥有两组核酸序列。一组序列包含在莫洛尼株小鼠C型病毒中，另一组序列包含在含有大鼠C型病毒的内源性反应中合成的DNA转录本中。用从大鼠C型病毒合成的DNA探针在哈维肉瘤病毒中检测到的核酸序列与在鼠肉瘤病毒克尔斯滕株中检测到的大鼠序列相关。这些结果支持了这样一种模型，即克尔斯滕和哈维肉瘤病毒都是通过小鼠C型病毒与大鼠细胞中的序列之间的重组或重配过程产生的，并表明成纤维细胞转化的信息可能包含在大鼠C型或细胞基因组中。
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