给予两种二氢麦角衍生物后大鼠脑电图的变化。

Changes in the rat electrocorticogram following administration of two dihydrogenated ergot derivatives.

作者信息

Carruthers-Jones D I, Depoortere H, Loew D M

出版信息

Gerontology. 1978;24 Suppl 1:23-33. doi: 10.1159/000212295.

Abstract

Dihydroergotoxine mesylate (DHET; active substance of Hydergine) and dihydro-beta-ergosine altered the sleep-wakefulness cycle of the rat by increasing wakefulness and decreasing slow wave and rapid eye movement sleep. In addition, power spectrum analysis indicated that, in comparison with placebo, DHET increased total power. Dihydro-beta-ergosine increased relative power in the theta-(4--8 Hz) and in the fast beta-(30--40 Hz) bands of ther electrocorticogram. The alterations in the sleep-wakefulness cycle and in the distribution of power in the rat electrocorticogram are discussed as possible indices of changes in alertness and attention.

摘要

甲磺酸双氢麦角毒碱（DHET；喜得镇的活性物质）和二氢-β-麦角异碱通过增加觉醒时间并减少慢波睡眠和快速眼动睡眠，改变了大鼠的睡眠-觉醒周期。此外，功率谱分析表明，与安慰剂相比，DHET增加了总功率。二氢-β-麦角异碱增加了脑电图θ波（4 - 8赫兹）和快β波（30 - 40赫兹）频段的相对功率。本文讨论了大鼠睡眠-觉醒周期和脑电图功率分布的变化，将其作为警觉性和注意力变化的可能指标。