Loew D M, Depoortere H, Buerki H R
Arzneimittelforschung. 1976;26(6):1080-3.
Investigations with four dihydrogenated ergot alkaloids, dihydroergotoxine, dihydroergonine, dihydroergostine and dihydro-beta-ergosine indicate that they exert similar dose dependent effects on the sleep-wakefulness cycle of the rat. The duration of wakefulness was increased, non-rapid eye movement (NREM) and, in particular, rapid eye movement (REM) sleep were shortened. 5-Hydroxytryptophan, but not apomorphine, induced similar changes of the rat sleep-wakefulness cycle. Neurochemical studies on rat brain biogenic amines indicate that dihydroergotoxine lowers homovanillic acid (HVA) levels and reduces HVA elevations after morphine or haloperidol in the striatum. In addition, the turnover of serotonin was slowed down and 5-hydroxyindoleacetic acid (5-HIAA) content in the whole brain was reduced. 5-HIAA elevation induced by clozapine was inhibited. These results suggest that the electroencephalographic changes in the rat produced by treatment with dihydrogenated ergot alkaloids reflect an enhanced level of vigilance and could be related to changes of brain biogenic amine metabolism.
对四种二氢麦角生物碱（双氢麦角毒碱、双氢麦角碱、双氢麦角斯汀和二氢-β-麦角新碱）的研究表明，它们对大鼠的睡眠-觉醒周期具有相似的剂量依赖性作用。清醒时间延长，非快速眼动（NREM）睡眠，尤其是快速眼动（REM）睡眠缩短。5-羟色氨酸而非阿扑吗啡可诱导大鼠睡眠-觉醒周期发生类似变化。对大鼠脑内生物胺的神经化学研究表明，双氢麦角毒碱可降低纹状体内高香草酸（HVA）水平，并减轻吗啡或氟哌啶醇给药后HVA的升高。此外，血清素的周转减慢，全脑5-羟吲哚乙酸（5-HIAA）含量降低。氯氮平诱导的5-HIAA升高受到抑制。这些结果表明，二氢麦角生物碱处理导致的大鼠脑电图变化反映了警觉性增强，可能与脑内生物胺代谢的改变有关。
