Song Jinhui, Lu Danchan, Zhang Li, Wang Yong, Wu Yanfei, Zhong Shuchang
Center for Rehabilitation Medicine, Department of Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, 310000, Zhejiang, China.
BMC Public Health. 2025 Nov 22;25(1):4419. doi: 10.1186/s12889-025-25509-8.
Sarcopenic obesity (SO), a metabolic disorder, may establish a bidirectional vicious cycle with stroke. However, the relationship between SO and stroke remains unclear. This study aims to analyze the association between these two diseases and to investigate the moderating effect of healthy lifestyle.
This cross-sectional study used data from the 2015 China Health and Retirement Longitudinal Study database. Participants meeting the inclusion criteria were classified based on the 2019 Asian Working Group for Sarcopenia (AWGS) criteria, and their history of stroke was recorded through questionnaires. The lifestyle assessments were based on four dimensions: smoking status, alcohol consumption, social engagement, and sleep duration. Logistic regression models examined the association between possible SO and stroke and the moderating role of a healthy lifestyle. Finally, a sensitivity analysis was performed.
A total of 5,401 individuals were included in the study, 185 of whom were diagnosed with possible SO. Compared to the non-SO group, the SO group had significantly higher rates of diabetes mellitus, cardiac disease, stroke, fall history, and drug use. Logistic regression analysis revealed a significant association between possible SO and stroke ( = 2.42, : 1.43–4.11, = 0.001). The association was weaker in the high score healthy lifestyle subgroup ( = 2.38, : 1.21–4.70, = 0.01) than in the low score subgroup ( = 2.43, : 1.02–5.80, = 0.045). Sensitivity analyses confirmed the stability of the results.
This study provides evidence that possible SO is significantly associated with stroke. Adhering to a healthy lifestyle, including abstaining from smoking and alcohol consumption, engaging in social activities, and maintaining adequate sleep, might attenuate this association.
Not applicable.
肌少性肥胖（SO）作为一种代谢紊乱疾病，可能与中风形成双向恶性循环。然而，SO与中风之间的关系仍不明确。本研究旨在分析这两种疾病之间的关联，并探讨健康生活方式的调节作用。
这项横断面研究使用了2015年中国健康与养老追踪调查数据库中的数据。根据2019年亚洲肌少症工作组（AWGS）标准对符合纳入标准的参与者进行分类，并通过问卷调查记录他们的中风病史。生活方式评估基于四个维度：吸烟状况、饮酒情况、社交参与度和睡眠时间。逻辑回归模型检验了可能的SO与中风之间的关联以及健康生活方式的调节作用。最后，进行了敏感性分析。
本研究共纳入5401名个体，其中185人被诊断为可能患有SO。与非SO组相比，SO组的糖尿病、心脏病、中风、跌倒史和药物使用发生率显著更高。逻辑回归分析显示，可能的SO与中风之间存在显著关联（β = 2.42，95%CI：1.43 - 4.11，P = 0.001）。在健康生活方式高分亚组中，这种关联较弱（β = 2.38，95%CI：1.21 - 4.70，P = 0.01），而在低分亚组中较强（β = 2.43，95%CI：1.02 - 5.80，P = 0.045）。敏感性分析证实了结果的稳定性。
本研究提供了证据表明可能的SO与中风显著相关。坚持健康的生活方式，包括戒烟限酒、参与社交活动和保持充足睡眠，可能会减弱这种关联。
不适用。
