Zhao Zhengmei, Cai Ruiting, Tao Lili, Sun Yuxiao, Sun Keping
Department of Geriatrics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Nutr. 2025 Apr 11;12:1452512. doi: 10.3389/fnut.2025.1452512. eCollection 2025.
Sarcopenic obesity is characterized by the coexistence of sarcopenia and obesity, which has been demonstrated to be linked to insulin resistance. The triglyceride-glucose (TyG) index is a novel surrogate indicator of insulin resistance. However, the relationship between sarcopenic obesity and the TyG index remains unclear. This population-based study aimed to investigate the association between TyG index and sarcopenic obesity in adults.
This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS), individuals aged over 45 years were categorized into sarcopenia, obesity, sarcopenic obesity, and control groups. Baseline characteristics were analyzed across these groups. Logistic regression models were employed to explore the association between the TyG index and sarcopenic obesity, adjusting for confounding variables. Subgroup analyses were conducted to explore the potential variations in this association across different demographic and clinical variables.
A total of 9,485 individuals were included in the study, with the sarcopenic obesity group exhibiting a higher TyG index (8.96 ± 0.61) compared to other groups ( < 0.001). A significant and independent association was observed between higher TyG index and increased likelihood of sarcopenic obesity, even after adjusting for confounders. Participants in the highest TyG index tertile had a 1.82-fold increase in the risk of sarcopenic obesity compared to those in the lowest tertile. Subgroup analyses revealed significant associations between TyG index and sarcopenic obesity across various demographic and clinical variables, particularly in individuals aged over 60 years, females, and those with chronic diseases.
The findings suggest a strong association between elevated TyG index and sarcopenic obesity in adults, independent of demographic and clinical factors. Further large-scale prospective studies are warranted to validate and expand upon these findings.
肌少症性肥胖的特征是肌少症和肥胖并存，已证明其与胰岛素抵抗有关。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的一种新型替代指标。然而，肌少症性肥胖与TyG指数之间的关系仍不清楚。这项基于人群的研究旨在调查成年人中TyG指数与肌少症性肥胖之间的关联。
本研究利用了中国健康与养老追踪调查（CHARLS）的数据，将45岁以上的个体分为肌少症组、肥胖组、肌少症性肥胖组和对照组。分析了这些组的基线特征。采用逻辑回归模型探讨TyG指数与肌少症性肥胖之间的关联，并对混杂变量进行了调整。进行亚组分析以探讨这种关联在不同人口统计学和临床变量中的潜在差异。
本研究共纳入9485名个体，肌少症性肥胖组的TyG指数（8.96±0.61）高于其他组（P<0.001）。即使在调整混杂因素后，仍观察到较高的TyG指数与肌少症性肥胖可能性增加之间存在显著且独立的关联。TyG指数最高三分位数的参与者患肌少症性肥胖的风险是最低三分位数参与者的1.82倍。亚组分析显示，TyG指数与肌少症性肥胖在各种人口统计学和临床变量中均存在显著关联，特别是在60岁以上的个体、女性和患有慢性疾病的个体中。
研究结果表明，成年人中TyG指数升高与肌少症性肥胖之间存在密切关联，且不受人口统计学和临床因素影响。有必要进行进一步的大规模前瞻性研究来验证和扩展这些发现。
