脾切除小鼠对单核细胞增生李斯特菌的抵抗力增强。
Enhanced resistance to Listeria monocytogenes in splenectomized mice.
作者信息
Skamene E, Chayasirisobhon W
出版信息
Immunology. 1977 Dec;33(6):851-8.
Abstract
Mice infected with live Listeria monocytogenes intravenously from 1 week to 3 months following splenectomy exhibit greatly enhanced antibacterial resistance to this micro-organism as compared to normal or sham-splenectomized mice. They survive a dose of Listeria 100 times higher than is the LD50 of this parasite for normal mice. Initially, the same number of viable micro-organisms lodge in the livers of splenectomized and normal hosts. However, within 24 h after infection, the number of viable Listeria which can be recovered from the livers of splenectomized animals is significantly reduced in comparison with control mice. This effect of splenectomy is transient and gradually disappears spontaneously within 3 months following splenectomy. Enhancement of anti-listerial resistance in splenectomized mice can be abrogated by the transfer of normal spleen cells. The presence of a normal splenic cell population that controls macrophage activation is postulated.
摘要
在脾切除术后1周内至3个月期间静脉内感染活单核细胞增生李斯特菌的小鼠，与正常或假脾切除小鼠相比，对这种微生物表现出大大增强的抗菌抵抗力。它们能耐受比正常小鼠该寄生虫半数致死剂量高100倍的李斯特菌剂量。最初，相同数量的活微生物寄居于脾切除和正常宿主的肝脏中。然而，感染后24小时内，与对照小鼠相比，从脾切除动物肝脏中可回收的活李斯特菌数量显著减少。脾切除的这种作用是短暂的，在脾切除术后3个月内会逐渐自发消失。脾切除小鼠抗李斯特菌抵抗力的增强可通过转移正常脾细胞而消除。推测存在控制巨噬细胞活化的正常脾细胞群体。
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