用单核细胞增生李斯特菌攻击的脾切除小鼠吞噬活性增强。
Increased phagocytic activity of splenectomized mice challenged with Listeria monocytogenes.
作者信息
Skamene E, Chayasirisobhon W, Konshavn P A
出版信息
Immunology. 1978 May;34(5):901-7.
Abstract
Adult splenectomized mice exhibit increased resistance to infection with Listeria monocytogenes. Phagocytosis, by reticulo-endothelial cells, of test particles (51Cr-labelled sheep erythrocytes) is the same in splenectomized and control mice. However, 24 h exposure to Listeria, which fails to influence phagocytic activity of normal mice, greatly enhances the blood clearance and liver uptake of the test particles in splenectomized mice. The presence of a cell population and/or product in the spleen which modulates macrophage activation upon the exposure to appropriate stimuli is postulated.
摘要
成年脾切除小鼠对单核细胞增生李斯特菌感染的抵抗力增强。脾切除小鼠和对照小鼠中，网状内皮细胞对测试颗粒（51Cr标记的绵羊红细胞）的吞噬作用相同。然而，正常小鼠接触李斯特菌24小时后，吞噬活性未受影响，但脾切除小鼠的测试颗粒血液清除率和肝脏摄取量大大增加。推测脾脏中存在一种细胞群和/或产物，在接触适当刺激后可调节巨噬细胞的激活。
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本文引用的文献
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Cellular resistance to infection.细胞抗感染能力。
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Enhanced resistance to Listeria monocytogenes in splenectomized mice.脾切除小鼠对单核细胞增生李斯特菌的抵抗力增强。
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