Rittenberg S C, Penn C W, Parsons N J, Veale D R, Smith H
J Gen Microbiol. 1977 Nov;103(1):69-75. doi: 10.1099/00221287-103-1-69.
Gonococci adapted to growth in chambers implanted subcutaneously into guinea pigs are resistant to killing by human serum. This resistance is lost after a few generations in vitro both in culture medium and in fluid taken from guinea-pig chambers. The rate of loss is too rapid to occur by mutation and selection. Furthermore, the resistance is regained after a few generations when bacteria from the first in vitro culture are inoculated back into guinea-pig chambers in vivo. Hence the loss of serum resistance in vitro and the gain in vivo are probably due to phenotypically controlled events. Such events could be important in the pathogenicity of Neisseria gonorrhoeae.
适应在皮下植入豚鼠的小室中生长的淋球菌对人血清的杀伤具有抗性。在体外，无论是在培养基中还是在取自豚鼠小室的液体中培养几代后，这种抗性就会丧失。丧失的速度太快，不可能通过突变和选择发生。此外，当将第一代体外培养的细菌重新接种到豚鼠体内的小室中几代后，抗性又会恢复。因此，体外血清抗性的丧失和体内抗性的恢复可能是由表型控制的事件引起的。这些事件可能在淋病奈瑟菌的致病性中起重要作用。
