Dupont B, Good R A, Hansen G S, Jersild C, Nielsen L S, Park B H, Svejgaard A, Thomsen M, Yunis E J
Proc Natl Acad Sci U S A. 1974 Jan;71(1):52-6. doi: 10.1073/pnas.71.1.52.
The genetic control of strong stimulation in the mixed lymphocyte culture reaction is determined by a separate gene (MLR-S) closely linked to the FOUR-locus of the HL-A chromosomal region. Three additional examples of siblings with recombination between FOUR-locus and MLR-S locus are presented which confirms the independent genetic control of mixed lymphocyte reaction from the control of HL-A antigens. The occurrence of two recombinant children in one family with four other children representing all possible HL-A haplotype-combinations, strongly supports the genetic mapping of the MLR-S determinants outside the HL-A chromosomal region. The experiments presented show that additional genes located within the HL-A region itself contribute with a weak stimulation of allogenic mixtures. These data are discussed in relation to the marginal stimulation of the mixed lymphocyte culture reaction which can be seen between unrelated individuals. It seems that a group of relatively histocompatible individuals can be defined by identity of the MLR-S locus but with differences on the weak MLC-determinants, and that this group for the purpose of clinical transplantation behaves as histocompatible individuals.
混合淋巴细胞培养反应中强刺激的遗传控制由一个与HL - A染色体区域的FOUR位点紧密连锁的独立基因(MLR - S)决定。本文展示了另外三个在FOUR位点和MLR - S位点之间发生重组的同胞实例,这证实了混合淋巴细胞反应的遗传控制独立于HL - A抗原的控制。在一个有四个孩子且代表所有可能的HL - A单倍型组合的家庭中出现了两个重组孩子,这有力地支持了MLR - S决定簇在HL - A染色体区域之外的遗传定位。所展示的实验表明,位于HL - A区域本身的其他基因对同种异体混合物有微弱的刺激作用。这些数据结合无关个体之间可见的混合淋巴细胞培养反应的边缘刺激进行了讨论。似乎可以通过MLR - S位点的一致性但在微弱的MLC决定簇上存在差异来定义一组相对组织相容性的个体,并且就临床移植而言,这组个体表现为组织相容性个体。