Weis P, Weis J S
Teratology. 1977 Dec;16(3):317-25. doi: 10.1002/tera.1420160311.
Exposure of developing eggs of the killifish, Fundulus heteroclitus, to 0.03 or 0.04 mg/l of methylmercuric chloride resulted in a variety of abnormalities. Percentage of axis formation was reduced somewhat, and many embryos developed cyclopia or intermediate conditions leading to cyclopia, reflecting interference with induction of the forebrain. Defects in the cardiovascular system also appeared in the form of failure of the heart to differentiate properly into chambers. The heart was a thin, feebly beating tube, incapable of causing the blood to circulate. Other tissues, however, continued developing fairly normally, and embryos showed spontaneous movement comparable to controls. Embryos with severe cardiovascular or optic defects did not hatch. Upon hatching, some embryos which had previously appeared normal were found to have skeletal malformations in the form of vertebral bends or the inability to uncurl from the position which they had while still inside the chorion. Exposure to the toxicant for shorter periods of time (6, 12, or 24 hours) reduced the incidence of abnormalities. The second day of development was found to be the most sensitive period.
将鳉鱼（Fundulus heteroclitus）发育中的卵暴露于0.03或0.04毫克/升的甲基氯化汞中会导致多种异常情况。轴形成的百分比有所降低，许多胚胎出现独眼畸形或导致独眼畸形的中间状态，这反映出对前脑诱导的干扰。心血管系统的缺陷也表现为心脏未能正常分化为心室。心脏是一根薄的、微弱跳动的管子，无法使血液循环。然而，其他组织继续正常发育，胚胎表现出与对照组相当的自发运动。有严重心血管或视觉缺陷的胚胎不会孵化。孵化时，一些之前看起来正常的胚胎被发现有骨骼畸形，表现为脊椎弯曲或无法从仍在绒毛膜内时所处的位置伸直。较短时间（6、12或24小时）接触毒物会降低异常发生率。发现发育的第二天是最敏感的时期。
