胃黏膜组胺在异丙肾上腺素对五肽胃泌素诱导的胃酸分泌的抑制作用中的意义。
Implication of gastric mucosal histamine in inhibition by isoprenaline of pentagastrin-induced gastric secretion.
作者信息
Lundell L, Svensson S E
出版信息
Br J Pharmacol. 1974 Sep;52(1):69-75. doi: 10.1111/j.1476-5381.1974.tb09688.x.
Abstract
1 The effect of isoprenaline on pentagastrin-induced gastric secretion was studied in conscious rats with Heidenhain pouches. The influence of isoprenaline on pentagastrin-induced release and formation of gastric mucosal histamine was also examined.2 Isoprenaline strongly inhibited pentagastrin-induced acid secretion, an inhibition which could not be overcome by increasing the dose of pentagastrin.3 Propranolol blocked the inhibitory effect of isoprenaline on pentagastrin-induced acid secretion.4 Isoprenaline enhanced pepsin secretion induced by pentagastrin, an effect which was blocked by propranolol.5 Isoprenaline reduced the increase in formation and release of gastric mucosal histamine following pentagastrin infusion, an inhibitory influence which was almost completely blocked by propranolol.6 The inhibition by isoprenaline of pentagastrin-induced acid secretion is tentatively related to alterations in gastric mucosal histamine occurring simultaneously.
摘要
在具有海登海因小胃的清醒大鼠中研究了异丙肾上腺素对五肽胃泌素诱导的胃酸分泌的影响。还检测了异丙肾上腺素对五肽胃泌素诱导的胃黏膜组胺释放和形成的影响。
异丙肾上腺素强烈抑制五肽胃泌素诱导的胃酸分泌，增加五肽胃泌素的剂量无法克服这种抑制作用。
普萘洛尔阻断了异丙肾上腺素对五肽胃泌素诱导的胃酸分泌的抑制作用。
异丙肾上腺素增强了五肽胃泌素诱导的胃蛋白酶分泌，普萘洛尔阻断了这一作用。
异丙肾上腺素减少了五肽胃泌素输注后胃黏膜组胺形成和释放的增加，普萘洛尔几乎完全阻断了这种抑制作用。
异丙肾上腺素对五肽胃泌素诱导的胃酸分泌的抑制作用初步与同时发生的胃黏膜组胺变化有关。
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