豚鼠离体心脏中的过敏反应：布立马胺对释放的组胺的正性肌力和变时作用的选择性抑制。
Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.
作者信息
Capurro N, Levi R
出版信息
Br J Pharmacol. 1973 Aug;48(4):620-8. doi: 10.1111/j.1476-5381.1973.tb08249.x.
Abstract
- Anaphylaxis was induced in the isolated heart of the guinea-pig in the presence of burimamide at concentrations of 4 x 10(-5)M and 2.7 x 10(-4)M.2. Burimamide did not affect the immunological release of histamine; however, it selectively antagonized the positive inotropic and chronotropic effects of released histamine. The antagonism of the positive chronotropic effect was concentration-dependent.3. Neither the negative dromotropic effect nor the decrease in coronary flow rate occurring during anaphylaxis were inhibited by burimamide.4. The results are in agreement with the double histamine receptor theory and suggest that, in the heart of the guinea-pig, H(2)-receptors are involved in the positive inotropic and chronotropic effects of released histamine, and H(1)-receptors in the negative dromotropic effect.
摘要
在存在浓度为4×10⁻⁵M和2.7×10⁻⁴M的布立马胺的情况下，对豚鼠离体心脏诱发过敏反应。
布立马胺不影响组胺的免疫释放；然而，它选择性地拮抗释放的组胺的正性变力和变时作用。正性变时作用的拮抗作用呈浓度依赖性。
布立马胺未抑制过敏反应期间出现的负性变传导作用或冠状动脉血流速率的降低。
结果与双组胺受体理论一致，表明在豚鼠心脏中，H₂受体参与释放的组胺的正性变力和变时作用，而H₁受体参与负性变传导作用。
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