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豚鼠离体心脏中的过敏反应：布立马胺对释放的组胺的正性肌力和变时作用的选择性抑制。

Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.

作者信息

Capurro N, Levi R

出版信息

Br J Pharmacol. 1973 Aug;48(4):620-8. doi: 10.1111/j.1476-5381.1973.tb08249.x.

DOI:10.1111/j.1476-5381.1973.tb08249.x
PMID:4132778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776149/
Abstract
  1. Anaphylaxis was induced in the isolated heart of the guinea-pig in the presence of burimamide at concentrations of 4 x 10(-5)M and 2.7 x 10(-4)M.2. Burimamide did not affect the immunological release of histamine; however, it selectively antagonized the positive inotropic and chronotropic effects of released histamine. The antagonism of the positive chronotropic effect was concentration-dependent.3. Neither the negative dromotropic effect nor the decrease in coronary flow rate occurring during anaphylaxis were inhibited by burimamide.4. The results are in agreement with the double histamine receptor theory and suggest that, in the heart of the guinea-pig, H(2)-receptors are involved in the positive inotropic and chronotropic effects of released histamine, and H(1)-receptors in the negative dromotropic effect.
摘要

  1. 在存在浓度为4×10⁻⁵M和2.7×10⁻⁴M的布立马胺的情况下，对豚鼠离体心脏诱发过敏反应。

  2. 布立马胺不影响组胺的免疫释放；然而，它选择性地拮抗释放的组胺的正性变力和变时作用。正性变时作用的拮抗作用呈浓度依赖性。

  3. 布立马胺未抑制过敏反应期间出现的负性变传导作用或冠状动脉血流速率的降低。

  4. 结果与双组胺受体理论一致，表明在豚鼠心脏中，H₂受体参与释放的组胺的正性变力和变时作用，而H₁受体参与负性变传导作用。

相似文献

1
Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.豚鼠离体心脏中的过敏反应：布立马胺对释放的组胺的正性肌力和变时作用的选择性抑制。
Br J Pharmacol. 1973 Aug;48(4):620-8. doi: 10.1111/j.1476-5381.1973.tb08249.x.
2
Pharmacological characterization of cardiac histamine receptors: sensitivity to H1-and H2-receptor agonists and antagonists.心脏组胺受体的药理学特性：对H1和H2受体激动剂及拮抗剂的敏感性
Eur J Pharmacol. 1975 Feb;30(2):328-35. doi: 10.1016/0014-2999(75)90117-x.
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Effects of the H1-antagonist promethazine and the H2-antagonist burimamide on chronotropic, inotropic and coronary vascular responses to histamine in isolated perfused guinea-pig hearts.H1拮抗剂异丙嗪和H2拮抗剂布立马胺对离体灌注豚鼠心脏中组胺引起的变时性、变力性及冠状血管反应的影响。
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Br J Pharmacol. 1987 Mar;90(3):459-66. doi: 10.1111/j.1476-5381.1987.tb11195.x.
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The inhibition of histamine uptake and metabolism by burimamide in the guinea-pig atrium and in mouse neoplastic mast cells, in vitro.在体外实验中，甲硫咪胺对豚鼠心房和小鼠肿瘤性肥大细胞中组胺摄取及代谢的抑制作用。
Br J Pharmacol. 1973 Oct;49(2):361-3. doi: 10.1111/j.1476-5381.1973.tb08384.x.
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Cardiac histamine receptors.心脏组胺受体
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Br J Pharmacol. 1975 Aug;54(4):511-21. doi: 10.1111/j.1476-5381.1975.tb07599.x.
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Res Commun Chem Pathol Pharmacol. 1974 Aug;8(4):635-51.
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Differentiation of H1- and H2-receptors mediating positive chrono- and inotropic responses to histamine on atrial preparations of the guinea-pig.豚鼠心房标本上介导组胺正性变时和变力反应的H1和H2受体的鉴别。
Agents Actions. 1974 Oct;4(4):217-21. doi: 10.1007/BF01965222.
10
In vitro anaphylaxis in guinea-pig skin: amplification by burimamide.豚鼠皮肤的体外过敏反应：丁咪胺的增强作用。
J Invest Dermatol. 1976 Dec;67(6):696-9. doi: 10.1111/1523-1747.ep12598572.

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Haeme oxygenase-1 and cardiac anaphylaxis.血红素加氧酶-1与心脏过敏反应
Br J Pharmacol. 2001 Dec;134(8):1689-96. doi: 10.1038/sj.bjp.0704427.
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Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.组胺的心脏毒性以及组胺在某些抗组胺药所致心律失常发生过程中的可能作用。
Drug Saf. 1999;21 Suppl 1:33-8; discussion 81-7. doi: 10.2165/00002018-199921001-00005.
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Classification and biological distribution of histamine receptor sub-types. 1975.组胺受体亚型的分类及生物学分布。1975年。
Agents Actions. 1994 Dec;43(3-4):97-115; discussion 116. doi: 10.1007/BF01986677.
5
Inotropic and electrophysiological effects of histamine on human ventricular heart muscle.组胺对人心室心肌的变力性和电生理效应。
J Physiol. 1982 Sep;330:111-23. doi: 10.1113/jphysiol.1982.sp014332.
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Klin Wochenschr. 1982 Sep 1;60(17):965-71. doi: 10.1007/BF01716956.
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本文引用的文献

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THE ACTION OF HISTAMINE ON THE ISOLATED HEART.组胺对离体心脏的作用。
Br J Pharmacol Chemother. 1963 Dec;21(3):450-61. doi: 10.1111/j.1476-5381.1963.tb02013.x.
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Histamine release and intracellular potentials during anaphylaxis in the isolated heart.离体心脏过敏反应期间的组胺释放与细胞内电位
Circ Res. 1960 Jul;8:713-23. doi: 10.1161/01.res.8.4.713.
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The action of histamine and 5-hydroxytryptamine on isolated mammalian atria.组胺和5-羟色胺对离体哺乳动物心房的作用。
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Effect of histamine and of the anaphylactic reaction on isolated guinea pig atria.组胺及过敏反应对豚鼠离体心房的影响。
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[Simple apparatus for perfusion].[简易灌注装置]
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The actions of histamine on the mammalian heart.组胺对哺乳动物心脏的作用。
J Pharmacol Exp Ther. 1967 Feb;155(2):271-8.
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A modified fluorometric procedure for tissue histamine and its distribution in various animals.一种改良的组织组胺荧光测定法及其在各种动物体内的分布。
J Pharmacol Exp Ther. 1969 Apr;166(2):285-90.
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Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
9
Hypersensitivity reactions of the heart: reduction of anaphylactic crisis by theophylline or glucagon.心脏的过敏反应：茶碱或胰高血糖素对过敏反应的缓解作用
Bull N Y Acad Med. 1971 Oct;47(10):1229.
10
Studies on heart anaphylaxis. 3. Effect of antigen and histamine on perfused guinea-pig heart.心脏过敏反应的研究。3. 抗原和组胺对豚鼠离体心脏灌流的影响。
Arch Int Pharmacodyn Ther. 1970 Mar;184(1):129-57.