Gristwood R W, Lincoln J C, Owen D A, Smith I R
Br J Pharmacol. 1981 Sep;74(1):7-9. doi: 10.1111/j.1476-5381.1981.tb09947.x.
Histamine release has been detected biologically after exposure of human right atrial biopsy samples to compound 48/80. Human right atrial samples contain large quantities of histamine, 1035 +/- 65 ng/g fresh weight. Exposure of untreated electrically paced atrial strips to compound 84/80, 300 micro/ml, caused an increase in the force of atrial contraction similar to that caused by histamine. Pretreatment of strips with cimetidine, 3.16 x 10(-5) M, prevented the inotropic response to compound 48/80. It is concluded that mast cell degranulation in human atrial tissue can cause sufficient release of histamine to modify the function of the heart.
在将人右心房活检样本暴露于化合物48/80后，已通过生物学方法检测到组胺释放。人右心房样本含有大量组胺，每克鲜重1035±65纳克。将未经处理的电刺激心房条暴露于300微克/毫升的化合物48/80，会导致心房收缩力增加，类似于组胺引起的收缩力增加。用3.16×10⁻⁵M西咪替丁预处理心房条，可防止对化合物48/80的变力反应。结论是人心房组织中的肥大细胞脱颗粒可导致足够的组胺释放，从而改变心脏功能。
