Haak H L, Hartgrink-Groeneveld C A, Guiot H F, Speck B, Eernisse J G, von Rood J J
Acta Haematol. 1977;58(6):339-52. doi: 10.1159/000207848.
The effect of conservative treatment of aplastic anaemia was evaluated retrospectively in 40 patients. No significant beneficial effect was provided by long-term high-dose oxymethalone in 20 patients or by metenolone, adrenstonolone, or testosterone in 14 patients. Splenectomy gave no improvement in the majority of cases, although in some it decreased the transfusion requirement. Immunosuppressive treatment was successful in 1 patient with a positive LE phenomenon. Until a specific treatment becomes available, the possibility offered by alternative treatment, e.g. bone marrow transplantation, in cases with poor prognostic parameters should be considered.
对40例再生障碍性贫血患者的保守治疗效果进行了回顾性评估。20例患者长期使用大剂量羟甲烯龙，14例患者使用美替诺龙、阿地雄酮或睾酮，均未产生明显有益效果。脾切除术在大多数病例中并无改善，不过在一些病例中减少了输血需求。免疫抑制治疗在1例LE现象阳性的患者中取得成功。在有特效治疗方法出现之前，对于预后参数较差的病例，应考虑采用替代治疗方法（如骨髓移植）的可能性。
