Pizzuto J, Conte G, Sinco A, Morales M, Avilés A, Ambríz R, Fernández A
Acta Haematol. 1980;64(1):18-24. doi: 10.1159/000207205.
124 adult patients with acquired aplastic anaemia (A.A.) were studied. 54 presented as severe A.A. (mean survival of the whole group, 2.7 months and in those who died, 2.5 months; mortality 88.8%) while 70 were mild (mean survival of the whole group, 27.2 months and in those who died , 22.7 months; mortality, 28.5%). Sixty-four did not live long enough to have adequate therapeutic trials or developed severe hepatic failure which made it impossible to continue treatment. The effectiveness of 78 therapeutic periods of treatment in the 60 evaluable cases was analyzed as to aetiology and severity. A response was obtained in 31 (40%), of which 24 were with oxymethalone; 17 showed improvement after 6 months of treatment. No conclusions could be drawn as to the effectiveness of methalone, cyclophosphamide and prednisone because of the limited number of treatments. In severe A.A. only one of 13 treatments was effective, whereas 30 of the 65 used in mild A.A. gave a response. Oxymethalone was used in 23 out of 41 (56%). The aetiology, sex and age appeared to have no influence on the response of the 60 patients analyzed. The only factor which appears useful for prognosis as to the effectiveness of treatment is the severity of the case.
对124例获得性再生障碍性贫血（A.A.）成年患者进行了研究。54例表现为重型A.A.（全组平均生存期为2.7个月，死亡患者为2.5个月；死亡率88.8%），而70例为轻型（全组平均生存期为27.2个月，死亡患者为22.7个月；死亡率28.5%）。64例患者生存期不足，无法进行充分的治疗试验，或出现严重肝功能衰竭，无法继续治疗。对60例可评估病例的78个治疗周期的治疗效果按病因和严重程度进行了分析。31例（40%）获得缓解，其中24例使用羟甲烯龙；17例在治疗6个月后病情改善。由于治疗次数有限，关于甲睾酮、环磷酰胺和泼尼松的疗效无法得出结论。在重型A.A.中，13次治疗中只有1次有效，而轻型A.A.使用的65次治疗中有30次有效。41例中有23例（56%）使用了羟甲烯龙。病因、性别和年龄似乎对所分析的60例患者的反应没有影响。对于治疗效果而言，唯一似乎对预后有用的因素是病情的严重程度。
