Hahn P, Hallberg O, Vikterlöf K J
AJR Am J Roentgenol. 1978 Jan;130(1):137-9. doi: 10.2214/ajr.130.1.137.
A group of 26 patients with operable carcinoma of the breast received postoperative radiotherapy plus adjuvant chemotherapy. Acute skin reactions were studied by clinical observation. There was a statistically significant difference (P less than .01) in the acute skin reactions in the chest wall area in those who received chemotherapy (81%) compared to the controls who received only radiotherapy (33%). Acute skin reactions began at the completion of postoperative radiotherapy and reached maximum severity 1-2 weeks later. They usually subsided after 4-6 weeks. No skin reactions were observed in the parasternal, supraclavicular fossa, or axillary regions. On the basis of these findings, postoperative radiotherapy combined with adjuvant chemotherapy is probably beneficial.
一组26例可手术乳腺癌患者接受了术后放疗加辅助化疗。通过临床观察研究急性皮肤反应。接受化疗的患者胸壁区域的急性皮肤反应（81%）与仅接受放疗的对照组（33%）相比，存在统计学显著差异（P<0.01）。急性皮肤反应在术后放疗结束时开始，1 - 2周后达到最严重程度。它们通常在4 - 6周后消退。胸骨旁、锁骨上窝或腋窝区域未观察到皮肤反应。基于这些发现，术后放疗联合辅助化疗可能是有益的。
