Ghossein N A, Stacey P, Alpert R T, Ager P J, Krishnaswamy V
Radiology. 1976 Nov;121(2):455-9. doi: 10.1148/121.2.455.
58 cases of breast cancer treated primarily by radiotherapy were evaluated to determine the optimum dose for local control. Of 36 patients with T1 + T2 lesions who had tumorectomy prior to radiotherapy, incomplete excision of tumor was demonstrated on microscopic examination in 18. The minimum tumor dose to the breast was 4,500 rads in 5 weeks. Treatment failed to control local tumor in only 2 (5%) and metastases in 1.26 (72%) remained disease-free for 2 to 9 years. Of the 22 patients with T3 + T4 lesions, treatment failed to control both local tumor and metastases in 12 (54%); in those who received 6,000 rads or less in 6 weeks, treatment failed to control any of these lesions. 4,500-5,500 rads controlled the tumor in 95% of those with NO + N1 disease, compared to only half of those with N2 + N3 tumors.
对58例主要采用放射治疗的乳腺癌患者进行评估，以确定局部控制的最佳剂量。在放疗前接受肿瘤切除术的36例T1 + T2病变患者中，18例经显微镜检查显示肿瘤切除不完全。乳房的最小肿瘤剂量为5周内4500拉德。治疗仅在2例（5%）中未能控制局部肿瘤，1例发生转移，26例（72%）无病生存2至9年。在22例T3 + T4病变患者中，12例（54%）的治疗未能控制局部肿瘤和转移；在6周内接受6000拉德或更少剂量的患者中，治疗未能控制任何这些病变。4500 - 5500拉德控制了95%的NO + N1疾病患者的肿瘤，而N2 + N3肿瘤患者中只有一半得到控制。
