Ward O C, Lam L K
Arch Dis Child. 1977 Nov;52(11):877-82. doi: 10.1136/adc.52.11.877.
The effect of bumetanide in infants with congenital heart disease presenting with cardiac failure was studied. The study was divided into acute (3 days) and long-term (mean 10.5 weeks) cases. A total of 12 male infants was included in the acute study and 13 cases were evaluated in the long-term study. The dose used in the acute study (0.015 mg/kg) was suboptimal; notwithstanding it was found to cause significant natriuresis and chloruresis. Bumetanide in doses varying in different infants from as little as 0.015 mg/kg on alternate days to as much as 0.10 mg/kg daily was shown to be an effective diuretic for long-term use. No side effects were observed in either study.
研究了布美他尼对患有心力衰竭的先天性心脏病婴儿的影响。该研究分为急性（3天）和长期（平均10.5周）病例。急性研究共纳入12名男婴，长期研究评估了13例。急性研究中使用的剂量（0.015mg/kg）并非最佳；尽管如此，仍发现它可引起显著的利钠和利尿作用。布美他尼的剂量在不同婴儿中有所不同，从低至隔日0.015mg/kg到高达每日0.10mg/kg，被证明是一种有效的长期利尿剂。两项研究均未观察到副作用。
