大肠杆菌抗体：一种免疫缺陷筛查试验。
Escherichia coli antibody: a screening test for immunodeficiency.
作者信息
Webster A D, Efter T, Asherson G L
出版信息
Br Med J. 1974 Jul 6;3(5922):16-8. doi: 10.1136/bmj.3.5922.16.
Abstract
Six patients suffering from recurrent chest infections were found to lack antibodies to a pooled antigen obtained from six different serotypes of commensal Escherichia coli bacteria. All had normal serum IgG concentrations, but five subsequently benefited from regular gammaglobulin injections. We suggest that the absence of such E. coli antibodies usually indicates a clinically significant defect in antibody production. This simple screening test is of use in the diagnosis of primary and secondary immunodeficiency disorders.
摘要
六名患有复发性胸部感染的患者被发现缺乏针对从六种不同血清型共生大肠杆菌细菌中提取的混合抗原的抗体。所有患者的血清IgG浓度均正常，但其中五名患者随后从定期注射丙种球蛋白中获益。我们认为，缺乏此类大肠杆菌抗体通常表明抗体产生存在临床上显著的缺陷。这种简单的筛查试验可用于原发性和继发性免疫缺陷疾病的诊断。
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本文引用的文献
1
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J Exp Med. 1963 Oct 1;118(4):619-26. doi: 10.1084/jem.118.4.619.
2
Antibiodies of the IgG, IgM, and IgA classes in newborn and adult sera reactive with gram-negative bacteria.新生儿和成人血清中与革兰氏阴性菌反应的IgG、IgM和IgA类抗菌抗体。
J Clin Invest. 1968 May;47(5):1053-62. doi: 10.1172/JCI105795.
3
Studies of urinary tract infections in infancy and childhood. IX. Determination of E. coli antibodies by a polyvalent antigen.
Acta Paediatr Scand. 1967 Nov;56(6):637-50. doi: 10.1111/j.1651-2227.1967.tb15990.x.
4
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Bull World Health Organ. 1972;46(1):67-79.
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