α链病伴临床、免疫学及组织学缓解。

Manousos O N, Economidou J C, Georgiadou D E, Pratsika-Ougourloglou K G, Hadziyannis S J, Merikas G E, Henry K, Doe W F

Br Med J. 1974 May 25;2(5916):409-12. doi: 10.1136/bmj.2.5916.409.

Clinical, immunological, and histological recovery in a patient with alpha-chain disease is described. The patient, a 27-year-old Greek man, presented with severe steatorrhoea, abdominal pain, oedema, and hypogammaglobulinaemia. Treatment with tetracycline produced only temporary remission. Intermittent therapy with prednisone and cyclophosphamide together with antibiotics was followed by clinical recovery, return of histological appearances of the small intestine to normal, and disappearance of free alpha-chain protein from the serum. The patient remained well one year later without treatment.

本文描述了一名α链病患者的临床、免疫学和组织学恢复情况。该患者为一名27岁的希腊男性，表现为严重脂肪泻、腹痛、水肿和低丙种球蛋白血症。四环素治疗仅产生短暂缓解。泼尼松和环磷酰胺联合抗生素的间歇性治疗后，患者临床康复，小肠组织学外观恢复正常，血清中游离α链蛋白消失。一年后，患者未经治疗仍状况良好。