Skinner J M, Manousos O N, Economidou J, Nicolaou A, Merikas G
Clin Exp Immunol. 1976 Jul;25(1):112-6.
An ileocaecal tumour in a patient with alpha-chain disease in remission was studied immunohistochemically by a quantitive immunoperoxidase method. The tumour which was histologically shown to be a plasmacytoma consisted of 68% alpha cells and 15% lambda cells; no kappa cells were found. Away from the tumour the pattern of immunoglobulin-producing cells was normal. It is concluded that the abnormal cell causing alpha-chain disease remains inactive and that the patient developed a plasmacytoma from a different cell clone.
对一名处于缓解期的α链病患者的回盲部肿瘤进行了免疫组织化学研究，采用定量免疫过氧化物酶法。组织学显示该肿瘤为浆细胞瘤，由68%的α细胞和15%的λ细胞组成；未发现κ细胞。在肿瘤以外的部位，产生免疫球蛋白的细胞模式正常。得出的结论是，导致α链病的异常细胞仍处于不活跃状态，且该患者是从不同的细胞克隆发展出了浆细胞瘤。
