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["移植细胞抗原"及其在人体不同器官中的检测]

["Transplanted cell antigen" and its detection in different human organs].

作者信息

Kriukova I N, Bobrova T S

出版信息

Biull Eksp Biol Med. 1977 Dec;84(12):690-3.

PMID:413594
Abstract

A cell membrane antigen was found in the continuous cell lines of epithelial origin, identical to the antigen revealed in the homogenates of human gastric mucosa. The antigen was detected with the aid of an antiserum against the solubilized membrane antigen from Hep-2 cells sorbed with a mixture of homogenates of human tissues--the lung, the liver, papillomatosis of the larynx and of the mammary gland. The described antigen was revealed in some (not all) adenocarcinomas of the stomach; it differs from carcinoembryonic Gold's antigen and from the secretory IgA component, it is not a structural component of D-type oncornoviruses (of primates) produced by Hep-2 cells, and does not seem to be coded by the genom of this virus.

摘要

在源自上皮组织的连续细胞系中发现了一种细胞膜抗原,它与人胃黏膜匀浆中所揭示的抗原相同。借助针对经人组织(肺、肝、喉乳头状瘤和乳腺)匀浆混合物吸附处理的Hep - 2细胞溶解膜抗原的抗血清,检测到了该抗原。在部分(并非全部)胃癌腺癌中发现了所述抗原;它不同于癌胚金氏抗原和分泌型IgA成分,不是Hep - 2细胞产生的(灵长类)D型肿瘤病毒的结构成分,似乎也不由该病毒的基因组编码。

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