糖皮质激素对人皮肤中抗原诱发的组胺释放的抑制作用。
Glucocorticoid inhibition of antigen-evoked histamine release from human skin.
作者信息
Greaves M W, Plummer V M
出版信息
Immunology. 1974 Sep;27(3):359-64.
Abstract
Prednisolone causes a dose-related inhibition of antigen-evoked histamine release from IgE-sensitized human skin . The effective concentrations are of the same order as are achieved in plasma therapeutically. Analysis of prednisolone inhibition shows that it acts on the second histamine release stage, antigen—antibody combination being unaffected. In contrast with the traditional view, our results show that, at least in human skin, glucocorticoids can inhibit antigen-evoked histamine release.
摘要
泼尼松龙可引起剂量相关的抑制作用，抑制抗原诱发的、来自IgE致敏人体皮肤的组胺释放。有效浓度与治疗时血浆中达到的浓度处于同一水平。对泼尼松龙抑制作用的分析表明，它作用于组胺释放的第二阶段，抗原-抗体结合不受影响。与传统观点相反，我们的结果表明，至少在人体皮肤中，糖皮质激素可以抑制抗原诱发的组胺释放。
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