非甾体抗炎药对大鼠腹膜肥大细胞组胺释放的抑制作用及其被钙逆转的现象。
The inhibition of histamine release from rat peritoneal mast cells by non-steroid anti-inflammatory drugs and its reversal by calcium.
作者信息
Lewis G P, Whittle B J
出版信息
Br J Pharmacol. 1977 Oct;61(2):229-35. doi: 10.1111/j.1476-5381.1977.tb08409.x.
Abstract
1 The non-steroid anti-inflammatory drugs, indomethacin, flufenamate and meclofenamate, inhibited the release of histamine from rat peritoneal mast cells induced by pharmacological or immunological challenge in vitro. 2 Anti-inflammatory steroids had little effect on histamine release from the mast cells. 3 Th inhibition of histamine release by the aspirin-like drugs was not prevented by incubation with glucose, unlike the inhibition of 2,4,dinitrophenol or antimycin-A. This suggests that the non-steroid anti-inflammatory compounds do not act by preventing the energy production from oxidative metabolism, required for histamine release. 4 The inhibition of the calcium ionophore A23187-induced histamine release by the aspirin-like drugs was reversed by an increase in the calcium concentration of the incubation medium. 5 The results suggest that the non-steroid anti-inflammatory compounds inhibit histamine release by actions on calcium influx into the mast cell, or on calcium mobilization or utilization within the mast cell.
摘要
- 非甾体抗炎药吲哚美辛、氟灭酸和甲氯灭酸，在体外可抑制由药理学或免疫性刺激诱导的大鼠腹腔肥大细胞释放组胺。2. 抗炎类固醇对肥大细胞释放组胺影响很小。3. 与2,4-二硝基苯酚或抗霉素A的抑制作用不同，阿司匹林类药物对组胺释放的抑制作用不会因与葡萄糖共同孵育而被阻止。这表明非甾体抗炎化合物并非通过阻止组胺释放所需的氧化代谢产生能量来发挥作用。4. 阿司匹林类药物对钙离子载体A23187诱导的组胺释放的抑制作用可通过提高孵育培养基中的钙浓度而逆转。5. 结果表明，非甾体抗炎化合物通过作用于钙离子流入肥大细胞，或作用于肥大细胞内的钙动员或利用来抑制组胺释放。
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