Falkiner F R, Keane C T, Dalton M, Clancy M T, Jacoby G A
J Clin Pathol. 1977 Aug;30(8):731-7. doi: 10.1136/jcp.30.8.731.
An outbreak of gentamicin- and tobramycin-resistant Pseudomonas aeruginosa infection occurred in a surgical ward over a three-month period. Resistant Ps. aeruginosa strains with the same serological, phage, and pyocin type were cultured from the urine of six patients. Identical organisms were found on urine bottles, bedpans, and the hands of attendant staff. Inadequate disinfection played a major role in cross-infection. Isolates of the epidemic strain from each of the patients and of an unrelated but similarly resistant Ps. aeruginosa from one of them could transfer resistance to a recipient strain of Ps. aeruginosa. Resistance to gentamicin, kanamycin, tobramycin, sulphonamides, and mercuric chloride was determined by R factors belonging to Pseudomonas incompatibility group P-3. Aminoglycoside resistance was due to acetylation.
在三个月的时间里，某外科病房发生了对庆大霉素和妥布霉素耐药的铜绿假单胞菌感染暴发。从六名患者的尿液中培养出了具有相同血清型、噬菌体和细菌素类型的耐药铜绿假单胞菌菌株。在尿瓶、便盆以及护理人员的手上发现了相同的微生物。消毒不充分在交叉感染中起了主要作用。从每位患者分离出的流行菌株以及从其中一名患者分离出的一株无关但同样耐药的铜绿假单胞菌，都能将耐药性转移给铜绿假单胞菌的受体菌株。对庆大霉素、卡那霉素、妥布霉素、磺胺类药物和氯化汞的耐药性由属于假单胞菌不相容群P-3的R因子决定。氨基糖苷类耐药性是由于乙酰化作用。
