突变体B6.CH(zl)和B6.M505与C57BL-6品系的血清学区分
Serological distinction of mutants B6.CH(zl) and B6.M505 from strain C57BL-6.
作者信息
Klein J, Hauptfeld M, Hauptfeld V
出版信息
J Exp Med. 1974 Oct 1;140(4):1127-32. doi: 10.1084/jem.140.4.1127.
Abstract
A quantitative serological difference was found between strains Hz1 and M505 carrying mutant H-2 haplotypes ba and bd, respectively, and the original strain B6(H-2(b)). The finding suggests that the mutations occurred in the H-2K(b) gene, and together with data on MLR and CML challenges the current concept of H-2 regions' involvement in immune reactions.
摘要
在分别携带突变型H-2单倍型ba和bd的Hz1和M505菌株与原始菌株B6(H-2(b))之间发现了定量血清学差异。这一发现表明突变发生在H-2K(b)基因中，并且与混合淋巴细胞反应（MLR）和细胞介导的淋巴细胞溶解（CML）的数据一起对目前关于H-2区域参与免疫反应的概念提出了挑战。
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